Synopsis of recent research by authors named "Dean Clift"
- Dean Clift's research focuses on protein degradation mechanisms, particularly through the TRIM (Tripartite Motif) family of E3 ubiquitin ligases, which play crucial roles in targeting proteins for degradation and regulating immune responses.
- Recent findings include the development of a novel bioPROTAC based on TRIM21 to target the HuR protein for degradation, as well as new insights into TRIM7's role in viral infection restriction and the ubiquitination mechanisms of lysine-less substrates.
- Clift's work also encompasses innovative diagnostic methods for detecting antibody responses to viral infections, such as those caused by SARS-CoV-2, and advances in understanding cell division processes mediated by SUMOylation during meiosis.
