Publications by authors named "Dean Bender"
Background: Lymphedema is a significant and disabling disorder affecting millions of people worldwide. Compression therapy is an important component of lifelong treatment but the specifics of appropriate compression garment selection and prescribing is not always well understood by practitioners and payers.
Method: An expert panel of the American Vein and Lymphatic Society was convened to write a Position Statement with explanations and recommendations for the appropriate compression therapy to be used in the treatment of lymphedema patients.
The International Compression Club (ICC) is a partnership between academics, clinicians and industry focused upon understanding the role of compression in the management of different clinical conditions. The ICC meet regularly and from these meetings have produced a series of eight consensus publications upon topics ranging from evidence-based compression to compression trials for arm lymphoedema. All of the current consensus documents can be accessed on the ICC website (http://www.
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- - A new three-step method for synthesizing the antifungal drug CANCIDAS (caspofungin acetate) starting from pneumocandin B0 is detailed in the study.
- - Key features of the synthesis involve creating a specific compound called phenylthioaminal, effectively reducing a primary amide in a single step with borane, and selectively substituting it with ethylenediamine.
- - The overall yield of the final product, CANCIDAS, achieved through this synthesis is 45%, highlighting its efficiency.
[reaction: see text] The relative and absolute configuration of the pneumocandin B(0) side chain has been established as (10R,12S)-dimethylmyristoyl by the stereocontrolled synthesis of both antipodes of the side chain acid and their comparison to a sample derived from the natural product.
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