Publications by authors named "Dean A Houston"
Article Synopsis
- The administration of intermittent parathyroid hormone (iPTH) stimulates bone formation by regulating the expression of key enzymes like PHOSPHO1, which is crucial for bone mineralization.
- In experiments with cultured osteoblasts, PHOSPHO1 expression was significantly inhibited after a few cycles of iPTH, while other enzymes like Alpl required more cycles for similar effects.
- In vivo studies showed that iPTH-treated wild-type mice had enhanced bone volume and mineralization markers, whereas mice lacking PHOSPHO1 did not exhibit these anabolic responses, indicating the importance of PHOSPHO1 in the bone-building effects of iPTH.
The fundamental process of endochondral ossification is under tight regulation in the healthy individual so as to prevent disturbed development and/or longitudinal bone growth. As such, it is imperative that we further our understanding of the underpinning molecular mechanisms involved in such disorders so as to provide advances towards human and animal patient benefit. The mouse metatarsal organ explant culture is a highly physiological ex vivo model for studying endochondral ossification and bone growth as the growth rate of the bones in culture mimic that observed in vivo.
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