Aesthetic and predictable correction of the inverted nipple.

Background: Multiple surgical techniques have been developed to correct the inverted nipple. No single technique is universally applicable for correction of all types of inverted nipple because different types have differing levels of fibrosis.

Objective: We describe a simple technique for providing long-term correction for the grade III severely inverted nipple without the use of dermal flaps.

Maximizing breast projection after free-nipple-graft reduction mammaplasty.

In 1922, Thorek described standard free-nipple reduction mammaplasty for gigantomastia. This technique provided a simple and effective way to perform reduction mammaplasty. However, the technique is frequently criticized for producing a breast and nipple with poor projection.

Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen.

Platelet thrombospondin interacts with plasminogen in a specific and saturable manner. Thrombospondin was found to specifically bind to plasminogen and the nonenzyme chain of plasmin. Preincubation of 125I-labeled thrombospondin with 30 mmol/L lysine was without effect in the binding of thrombospondin to immobilized plasminogen; preincubation of 125I-labeled plasminogen with 30 mmol/L lysine, on the other hand, significantly reduced the binding of plasminogen to immobilized thrombospondin, suggesting that the interaction of thrombospondin with plasminogen is not the direct result of the lysine binding sites of plasminogen.

Antithrombin, prekallikrein, and fibronectin levels in surgical patients.

Antithrombin (AT), prekallikrein (PK), and fibronectin (FN) levels were measured in the plasma of 290 patients. The mean (+/- SD) lowest AT level measured in 287 patients was 70% +/- 18% (normal, 75% to 120% of control). The mean lowest AT level in 81 septic patients (49% +/- 17%) was significantly lower than in the 206 patients without sepsis (78% +/- 22%).