Hospitalized prenatal and childhood infections and obesity in Danish male conscripts.

Purpose: We examined the relation between early life infections and adult obesity.

Methods: A cohort of Danish males who underwent mandatory army fitness examinations was studied. Hospitalizations for childhood infections and their mothers' hospitalization for infection during pregnancy were identified via the Danish National Registry of Patients.

Pre-filled normal saline syringes to reduce totally implantable venous access device-associated bloodstream infection: a single institution pilot study.

Flushing totally implantable venous access devices (TIVADs) with manually filled saline syringes may increase contamination and catheter-related bloodstream infection (CRBSI). We used a retrospective cohort study to assess the impact of changing from manually filled syringes to manufactured pre-filled syringes on the frequency of CRBSI in 718 TIVADs. Manually filled syringes were used in 269 patients and pre-filled syringes in 449.

The impact of a Massachusetts state-sponsored educational program on antimicrobial stewardship in acute care hospitals.

Our objective was to characterize barriers to antimicrobial stewardship implementation in acute care hospitals in Massachusetts, as well as to identify successful existing antimicrobial stewardship practices. We show that a statewide antimicrobial stewardship educational program had a significant effect on implementation of antimicrobial stewardship programs and improvement of existing programs.

Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction.

New therapies are needed to prevent heart failure after myocardial infarction (MI). As experimental treatment strategies for MI approach translation, safety and efficacy must be established in relevant animal models that mimic the clinical situation. We have developed an injectable hydrogel derived from porcine myocardial extracellular matrix as a scaffold for cardiac repair after MI.

Prevalence and correlates of pubic hair grooming among low-income Hispanic, Black, and White women.

The purpose of this paper was to describe pubic hair grooming behaviors (shaving, waxing, trimming or dyeing) and the extent to which grooming was related to demographic characteristics and sexual history among low-income Hispanic, Black, and White women. Data were collected from 1677 women aged 16-40 years between July 2010 and August 2011 as part of a larger study. Participants completed a cross-sectional written survey.

The magnitude and nature of unfunded published cardiovascular research.

Objectives: The aim of this study was to determine the extent, type (e.g., staff, equipment), and sources of funding for published cardiovascular research.

Assessment of the burden of mandatory reporting of health care-associated infection using the National Healthcare Safety Network in Massachusetts.

An online survey was sent to 73 facilities in December 2010 to assess the time commitment, staff involvement, and methods used in reporting health care-associated infection (HAI) events through the National Healthcare Safety Network in Massachusetts. Of the 65 respondents, 45% reported electronically importing at least a portion of their data. Facilities that reported using electronic import spent fewer hours per week on data collection and entry than those performing manual data entry.

Obstructive coronary atherosclerosis and ischemic heart disease: an elusive link!

In the current pathophysiological model of chronic ischemic heart disease (IHD), myocardial ischemia and exertional angina are caused by obstructive atherosclerotic plaque, and the clinical management of IHD is centered on the identification and removal of the stenosis. Although this approach has been in place for years, several lines of evidence, including poor prognostic impact, suggest that this direct relationship may present an oversimplified view of IHD. Indeed, a large number of studies have found that IHD can occur in the presence or absence of obstructive coronary artery disease and that atherosclerosis is just 1 element in a complex multifactorial pathophysiological process that includes inflammation, microvascular coronary dysfunction, endothelial dysfunction, thrombosis, and angiogenesis.