Projecting the 10-year costs of care and mortality burden of depression until 2032: a Markov modelling study developed from real-world data.

Background: Based on real-world data, we developed a 10-year prediction model to estimate the burden among patients with depression from the public healthcare system payer's perspective to inform early resource planning in Hong Kong.

Methods: We developed a Markov cohort model with yearly cycles specifically capturing the pathway of treatment-resistant depression (TRD) and comorbidity development along the disease course. Projected from 2023 to 2032, primary outcomes included costs of all-cause and psychiatric care, and secondary outcomes were all-cause deaths, years of life lived, and quality-adjusted life-years.

Risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination: a population-based cohort study.

Background: Case reports suggest that SARS-CoV-2 infection could lead to immune dysregulation and trigger autoimmunity while COVID-19 vaccination is effective against severe COVID-19 outcomes. We aim to examine the association between COVID-19 and development of autoimmune diseases (ADs), and the potential protective effect of COVID-19 vaccination on such an association.

Methods: A retrospective cohort study was conducted in Hong Kong between 1 April 2020 and 15 November 2022.

Boron Modified Bifunctional Cu/SiO Catalysts with Enhanced Metal Dispersion and Surface Acid Sites for Selective Hydrogenation of Dimethyl Oxalate to Ethylene Glycol and Ethanol.

Boron (B) promoter modified Cu/SiO bifunctional catalysts were synthesized by sol-gel method and used to produce ethylene glycol (EG) and ethanol (EtOH) through efficient hydrogenation of dimethyl oxalate (DMO). Experimental results showed that boron promoter could significantly improve the catalytic performance by improving the structural characteristics of the Cu/SiO catalysts. The optimized 2B-Cu/SiO catalyst exhibited excellent low temperature catalytic activity and long-term stability, maintaining the average EG selectivity (Sel.

Environmental implications of reduced electricity consumption in Wuhan during COVID-19 outbreak: A brief study.

Due to the COVID-19 outbreak, Wuhan was locked down from 23 January 2020 to 8 April 2020, a total of 76 days. It is well known that the electricity consumption is a direct reflection of human activity. During the lockdown of Wuhan, most of human activities were forbidden.

Identification of Long Noncoding RNAs lnc-DC in Plasma as a New Biomarker for Primary Sjögren's Syndrome.

Objective: To evaluate the plasma levels of lnc-DC in primary Sjögren's syndrome (pSS) patients and investigate the potential associations between lnc-DC and disease activity.

Methods: In this study, we recruited 358 enrollments, including 127 pSS patients without immune thrombocytopenia (ITP), 22 pSS patients with ITP, 50 systemic lupus erythematosus (SLE) patients, and 50 patients with rheumatoid arthritis (RA) and 109 healthy individuals, from Xuzhou Central Hospital. The expression of anti-SSA and anti-SSB was detected by enzyme-linked immunosorbent assay (ELISA).

Clinical application of the AUC-guided dosage adjustment of docetaxel-based chemotherapy for patients with solid tumours: a single centre, prospective and randomised control study.

Background: Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied efficacy, likely occur because of differences in the pharmacokinetics (PK) and pharmacodynamics of patients. Thus, a feasible dosage adjustment method is needed.

Pharmacokinetics-based Dose Management of 5-Fluorouracil Clinical Research in Advanced Colorectal Cancer Treatment.

Objective: The study aimed to explore the efficacy of pharmacokinetic-based 5-fluorouracil dose management by plasma concentration test in advanced colorectal cancer treatment.

Methods: 153 samples of advanced colorectal cancer patients were enrolled and randomly assigned to a control group and an experimental group. All patients received double-week chemotherapy with 5- fluorouracil (four weeks were used as one period), and chemotherapy duration ranged from 2 to 6 periods.

(BEDT-TTF)Cu(HCOO): An Organic-Inorganic Hybrid Conducting Magnet.

A dual-functional organic-inorganic hybrid (BEDT-TTF)Cu(HCOO) () (BEDT-TTF=bis(ethylenedithio)tetrathiafulvalene) was obtained through the electrochemical oxidation of neutral BEDT-TTF in the presence of an ammonium salt of the one-dimensional copper-formate framework [(CH)NH]Cu(HCOO) in a CHCl-CHOH solution. Compound  was composed of organic donor BEDT-TTF⋅ in a θ-phase arrangement and Jahn-Teller distorted (4,4) grid anion sheets [Cu(HCOO)] with 1/2. We identified the material as a semiconductor with values of =10 S cm.

(BEDT-TTF)Cu(HCOO): An Organic-Inorganic Hybrid Conducting Magnet.

10.1002/open.201700041.

{5,10,15,20-Tetra-kis[4-(hex-yloxy)phen-yl]porphyrinato}nickel(II).

The mol-ecule of the title compound, [Ni(C(68)H(76)N(4)O(4))], is located on a crystallographic inversion center. The Ni-N distances within the square-shaped coordination environment are 1.951 (2) and 1.

{5,10,15,20-Tetra-kis[4-(oct-yloxy)phen-yl]porphyrinato}copper(II).

In the title compound, [Cu(C(76)H(92)N(4)O(4))], the central Cu(II) ion is situated on an inversion centre. The porphyrinate core exhibits a nearly planar conformation [maximum deviation = 0.027 (3) Å], with Cu-N distances of 1.

{meso-Tetra-kis[p-(hept-yloxy)phen-yl]-porphyrinato}silver(II).

The title compound, [Ag(C(72)H(84)N(4)O(4))], crystallizes with the Ag(II) cation on a centre of symmetry. The macrocyclic 24-membered ring core is planar with a mean deviation of 0.0311 (15) Å and the four-coordinate Ag(II) cation fits into its center, at 2.

[(1,3-Benzothia-zol-2-yl)amino-carbon-yl]meth-yl piperidine-1-carbodithio-ate monohydrate.

In the title compound, C(15)H(17)N(3)OS(3)·H(2)O, the piperidine ring has a chair conformation. The crystal structure is stabilized by weak inter-molecular N-H⋯O, O-H⋯N and O-H⋯O hydrogen-bonding inter-actions.

[meso-Tetra-kis(4-heptyl-oxyphen-yl)porphyrinato]nickel(II).

In the title compound, [Ni(C(72)H(84)N(4)O(4))], the four-coordinate Ni(II) ion in the middle of the planar 24-membered porphyrin ring is located on a crystallograpic inversion center, with Ni-N distances of 1.946 (2)-1.951 (2) Å.

Molecular interface effect of heterogeneous molecular junctions consisting of nonfluorinated and fluorinated phthalocyanines.

We report the tunneling behavior of homogeneous and heterogeneous molecular junctions using p-type molecules of iron phthalocyanine (FePc), phthalocyanine (H(2)Pc), and copper(II) octaalkoxyl substituted phthalocyanine (CuPcOC8) and n-type molecule of copper hexadecafluorophthalocyanine (F(16)CuPc). The molecular films formed on the electrode surfaces were inspected by X-ray photoelectron spectroscopy (XPS). The measured characteristic tunneling curves of single-component phthalocyanines revealed comparable energy gaps for homogeneous tunneling junctions using the photoemission method.

Charge-transfer effect at the interface of phthalocyanine-electrode contact studied by scanning tunneling spectroscopy.

Scanning tunneling microscopy (STM) and spectroscopy (STS) are used in this work to investigate the charge-transfer effect at the molecule-substrate interface of substituted metal phthalocyanines. STS results revealed that the apparent energy gaps for both fluorinated phthalocyanines and unsubstituted phthalocyanines are essentially the same, which agree with the hybrid density functional calculations. More interestingly, there is a systematic shift of the energy level of valence bands, possibly as the result of charge-transfer effect at the molecule-substrate interface.

Tunneling characteristics of octadecyl derivatives on tin and indium electrodes.

In this paper we report the tunneling behavior based on the capillary tunnel junctions of n-octadecylmercaptan (C18H37SH), octadecylamine (C18H37NH2), nonadecanoic acid (C17H35COOH), octadecanol (C18H370H), and n-iodooctadecane (C18H37I), sandwiched between tin and indium electrodes utilizing the naturally existing oxide surfaces, respectively. The surfaces of the electrodes were examined by X-ray diffraction (XRD), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS) methods, and the self-assembled monolayers adsorbed on the electrode surfaces were inspected by contact angle measurements and XPS. The measured characteristic curves on tin electrode indicated a sequence of energy gaps associated with the specimen: deltaC17H35COOH > deltaC18H37OH > deltaC18H37SH > deltaC18H37NH2 > deltaC18lH37I.