Publications by authors named "DeJonge C"
Article Synopsis
- Current treatments for dysphagia in ALS fail to address the root causes like tongue weakness and muscle atrophy, prompting a study using the LCN-SOD1 mouse model to explore this issue.
- The study followed 125 LCN-SOD1 offspring to analyze limb strength's impact on dysphagia and survival rates; results showed a high occurrence of swallowing difficulties in mixed phenotype mice compared to hindlimb phenotype mice.
- Findings indicated that both mouse groups had significant tongue muscle atrophy, supporting the potential of this model for developing targeted treatments for dysphagia in ALS.
Human embryonic stem cell (hESC) lines are derived from the inner cell mass (ICM) of preimplantation human blastocysts obtained on days 5-6 following fertilization. Based on their derivation, they were once thought to be the equivalent of the ICM. Recently, however, studies in mice reported the derivation of mouse embryonic stem cell lines from the epiblast; these epiblast lines bear significant resemblance to human embryonic stem cell lines in terms of culture, differentiation potential and gene expression.
View Article and Find Full Text PDFThe predictive value of sperm chromatin integrity for pregnancy outcome following in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) was studied in 24 men attending a university-based assisted reproductive techniques laboratory using the flow cytometric sperm chromatin structure assay (SCSA). The SCSA is a measure of the susceptibility of sperm DNA to low pH-induced denaturation in situ. The mean percentage of spermatozoa in the neat sample demonstrating DNA denaturation was significantly lower in the seven men that initiated a pregnancy (15.
View Article and Find Full Text PDFA possible relationship between transforming growth factor beta receptor type I (TbetaRI) and type II (TbetaRII) protein expression in human granulosa cells and the quality of preimplantation embryo development in vitro was studied using immunoblot analysis of TbetaRI and TbetaRII in hyperstimulated granulosa cells and morphological assessment of the cleavage potential of the zygotes in vitro. Washed granulosa cells were collected from View Article and Find Full Text PDF