Angiographic leakage of polypoidal choroidal vasculopathy on indocyanine angiography.

Background: There is no detailed report about the angiographic leakage of polypoidal choroidal vasculopathy (PCV) lesions on indocyanine green (ICG) angiography. This study aimed to investigate the angiographic leakage of polypoidal lesions in PCV on ICG angiography.

Methods: One hundred and forty-four eyes of 137 patients diagnosed as PCV were prospectively observed.

[Reversal effect of haloperidol on doxorubicin resistance and chloride channel inhibition in erythroleukemic cell K562/Dox].

Objective: To investigate the reversal effect of haloperidol (Hal) on doxorubicin (Dox) resistance and its inhibition effect on P-glycoprotein and swelling-activated chloride channel in Dox-resistant erythro-leukemic cell line K562/Dox.

Methods: Tumor cell proliferation was measured by LDH assay. mRNA expressions of P-glycoprotein (MDR1), glutathione S-transferase Pi (GSTpi) and MDR-associated protein (MRP) of K562/Dox treated with Hal were assayed by RT-PCR.

[The conversion of macular function in diabetic macular edema after vitreous surgery].

Objective: To evaluate the conversion of macular function in diabetic macular edema (DME) after vitreous surgery.

Methods: Seventeen eyes of 16 patients were assessed after pars plana vitrectomy for DME. Multifocal electroretinogram (mfERG) techniques were used to evaluate the effects of treatment on macular visual function, and retinal foveal thickness was determined by optical coherence tomography before and after vitrectomy.

[The study on binocular visual field summation and its possible mechanism].

Purpose: To observe the summation effect of binocular visual field in persons with normal or abnormal visual field and study the validity of four kinds of theory (best eye, average eye, best location, binocular summation) on binocular visual field formation.

Methods: The monocular and binocular visual field were tested in 15 cases with normal visual field and 58 cases of different kinds of ocular diseases with abnormal visual field.

Results: The mean rates of summation in normal visual field group and abnormal group were 93.

Exploration of multifocal rod electroretinograms recording in human.

Purpose: To test the feasibility of recording rod multifocal electroretinograms (ERG) in humans and observe appropriate recording conditions.

Methods: Multifocal rod ERG were recorded using a stimulus array of 61 equalsized hexagons in two normal subjects after the dark adaptation. Flashes were blue (W47B).

[Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population].

Aim: To assess the effect of gender on genetic polymorphism of cytochrome CYP2C19 in Chinese population.

Methods: The genetic polymorphism of 140 healthy Chinese were analysed by PCR-RFLP (restriction fragment length polymorphism).

Results: Of 52 genotyped male subjects, 23 (44.

Fundus analysis and visual prognosis of macular hemorrhage in pathological myopia without choroidal neovasculopathy.

Purpose: To analysis and evaluate the fundus characteristics and visual prognosis of macular hemorrhage in pathological myopia without choroidal neovasculopathy.

Methods: Thirty-seven patients (38 eyes) of pathological myopia with macular hemorrhage and without choroidal neovascularization (CNV) underwent color photograph and fundus fluorescein angiography (FFA) examinations. Indocyanine green angiography (ICGA) was also performed on 11 patients (11 eyes).

Impairment of optic path due to radiotherapy for nasopharyngeal carcinoma.

Purpose: To evaluate the impairment of optic path caused by radiotherapy for nasopharyngeal carcinoma (NPC).

Methods: Visual evoked potential was used to evaluate the functional impairment of optic path by an 8 MV linear accelerator or 60Co gamma-ray radiotherapy in 63 (23 women and 40 men) patients with nasopharyngeal carcinoma before radiotherapy, at the end of radiotherapy, 6 months and 1, 2 and 3 years after their radiotherapy respectively.

Results: In the female group, the latency of VEP elicited by the three types of elements significantly delayed 2 and 3 years after radiotherapy than that before radiotherapy, at the end of radiotherapy, 6 months and 1 year after radiotherapy; there were no significant difference among VEP amplitudes elicited by the three types of elements before and after radiotherapy.

Scotopic sensitivity of central retina in early age-related macular degeneration.

Purpose: To test scotopic sensitivity and investigate whether there is rod system dysfunction in the central retina in early age-related macular degeneration (AMD).

Methods: Scotopic (450 nm stimulus) and photopic (white light stimulus) sensitivity in 24 patients with early AMD was measured at 81 loci in central 25 degrees of retina, and compared with the age-match normal controls.

Results: Mean scotopic sensitivity of AMD patients was significantly lower than that of the normal controls.