Isolation and Characterization of Sesquiterpene Lactones From Syneilesis aconitifolia and Evaluation of Their Anti-Breast Cancer Activity.

Two undescribed sesquiterpene lactones (1 and 2), along with two known analogs (3 and 4), were isolated from Syneilesis aconitifolia. Their structures and absolute configurations were elucidated using spectroscopic analysis, ECD calculations, and single crystal x-ray diffraction. Compound 3 exhibited the highest cytotoxic activity against 4T1 cells, with an IC value of 10.

Two New Phenylpropanoids and a Polyphenol with Anti-Cervical Cancer Activity from Smilax china L.

Two novel phenylpropanoids (compounds 1 and 2) and 11 known compounds were isolated from Smilax china L. Their structures were determined by NMR (1D and 2D) and high-resolution electrospray ionization mass spectrometry. Further, the cytotoxic activity of all the isolated compounds against HeLa, 4T1, and U251 tumor cells was evaluated using the cell counting kit-8 assay, revealing that compound 13 showed significant cytotoxicity toward HeLa cells.

A Novel Real-Valued DOA Algorithm Based on Eigenvalue.

To solve the high complexity of the subspace-based direction-of-arrival (DOA) estimation algorithm, a super-resolution DOA algorithm is built in this paper. However, in this method, matrix decomposition is required for each search angle. Therefore, in this paper, real-valued processing is used to reduce the scanning range by half, which is less effective in algorithm complexity.

Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells.

Aim: To investigate the effect of fenugreek lactone (FL) on palmitate (PA)-induced apoptosis and dysfunction in insulin secretion in pancreatic NIT-1 β-cells.

Methods: Cells were cultured in the presence or absence of FL and PA (0.25 mmol/L) for 48 h.

[Effect of sinomenine on adjuvant arthritis and its mechanisms].

Objective: To discuss the anti-inflammatory mechanism of sinomenine on inflammatory media in joint of adjuvant arthritis rats.

Method: Rats were randomly divided into the normal group and the model group, the prednisone group, the small, medium, large of sinomenine group (30, 60, 120 mg x kg(-1)). Except for the rats in the normal group, animals were modeled to adjuvant arthritiswith freund's complete adjuvant.

[Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse].

Objective: To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.

Methods: BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.

Results: The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days.

[Stress and hippocampus].

This review summarizes the present advance of effects of stress on hippocampal structure and function and the role of hippocampus in feedback regulation of thalamic-pituitary-adrenocortical (HPA) axis during stress. It shows that stress can affect hippocampal structure and function, on the other hand, the hippocampus can also suppress the stress reaction through the feedback regulation of HPA axis, but chronic stress can attenuate this regulation, then significantly impair its structure and function.