Publications by authors named "De-rong Liang"
Objective: To investigate the association of CYP3A5 and MDR1 genetic polymorphisms with the concentration/ dose (C/D) ratio of tacrolimus for the feasibility of individualized medication.
Methods: The concentration of tacrolimus was detected by enzyme-multiplied immunoassay technique, and was adjusted by weight and dosage to C/D ratios. The single nucleotide polymorphisms of CYP3A5 A6986G and MDR1 C3435T, G2677T/ A, T1236C were determined by TaqMan RT-PCR.
[Clinical pharmacokinetics/pharmacodynamics study on pazufloxacin methanesulphonate injection].
Sichuan Da Xue Xue Bao Yi Xue Ban
July 2009
Objective: To identify rational dosage regimen for pazufloxacin methanesulphonate injection through a pharmacokinetics/pharmacodynamics (PK/PD) study.
Methods: Pazufloxacin methanesulphonate at the doses of 300 mg and 500 mg were injected to 24 healthy volunteers. The plasma concentrations of pazufloxacin were measured by RPHPLC-UV.
Purpose: HAb18G/CD147 is a hepatocellular carcinoma (HCC)-associated antigen. We developed iodine (131I) metuximab injection (Licartin), a novel 131I-labeled HAb18G/CD147-specific monoclonal antibody Fab'2 fragment, and evaluated its safety, pharmacokinetics, and clinical efficacy on HCC in Phase I/II trials.
Methods And Materials: In a Phase I trial, 28 patients were randomly assigned to receive the injection in 9.
[A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China].
Zhonghua Jie He He Hu Xi Za Zhi
January 2006
Article Synopsis
- The study looked at causes of community-acquired pneumonia (CAP) in adults in China, focusing on how prior antibiotic use and PORT classification relate to the germs involved and the level of drug resistance.
- Pathogens were identified in 53.1% of patients studied, with Mycoplasma pneumoniae being the most common culprit, followed by Streptococcus pneumoniae and Haemophilus influenzae.
- Findings highlight a significant presence of atypical pathogens in CAP cases, with over 75% of Streptococcus pneumoniae strains showing resistance to common antibiotics, signaling a need for better treatment strategies.
Objective: To evaluate the efficacy and safety of cefditoren pivoxil in treatment of respiratory infections.
Methods: 199 cases of respiratory infection confirmed by etiological and clinical examinations were treated with cefditoren pivoxil tablets taken orally. Therapeutic evaluation was conducted among 196 cases and safety evaluation was conducted among 199 cases.