The Long Non-Coding RNA AC006329.1 Facilitates Hepatocellular Carcinoma Progression and Metastasis by Regulating miR-127-5p/SHC3/ERK Axis.

Purpose: Hepatocellular carcinoma(HCC) is the most common type of liver cancer and the sixth largest common cancer worldwide. Although surgical resection, hepatic arterial chemoembolization, targeted drugs and immunotherapy are currently available, the mortality of advanced patients remains high. Therefore, new therapeutic targets are urgently needed.

Enhancing the Activity of Surface Immobilized Antimicrobial Peptides Using Thiol-Mediated Tethering to Poly(ethylene glycol).

Considering the need for versatile surface coatings that can display multiple bioactive signals and chemistries, the use of more novel surface modification methods is starting to emerge. Thiol-mediated conjugation of biomolecules is shown to be quite advantageous for such purposes due to the reactivity and chemoselectivity of thiol functional groups. Herein, the immobilization of poly(ethylene glycol) (PEG) and antimicrobial peptides (AMPs) to silica colloidal particles based on thiol-mediated conjugation techniques, along with an assessment of the antimicrobial potential of the functionalized particles against Pseudomonas aeruginosa and Staphylococcus aureus is investigated.

[Quantification on driving forces for spatiotemporal evolution of precipitation-use efficiency of grassland across recent two decades in Otog Banner, Inner Mongolia, China].

Precipitation use efficiency (PUE) is an effective index to evaluate the relationship between grassland productivity and precipitation in arid and semi-arid regions. To explore the driving mechanism of climate change and human activities on grassland PUE, we used the improved CASA model to estimate net primary productivity (NPP) of grassland from 2001 to 2020 in Otog Banner, Inner Mongolia. The PUE was obtained combining with the spatial interpolation data of precipitation.

Microparticles of High Entropy Alloys Made by Laser-Induced Forward Transfer.

The controlled deposition of CoCrFeNiMo0.2 high-entropy alloy (HEA) microparticles was achieved by using laser-induced forward transfer (LIFT). Ultra-short laser pulses of 230 fs of 515 nm wavelength were tightly focused into ∼2.

Two-Photon Dual-Emissive Carbon Dot-Based Probe: Deep-Tissue Imaging and Ultrasensitive Sensing of Intracellular Ferric Ions.

Carbon dots (CDs)-based nanoparticles have been extensively explored for biological applications in sensing and bioimaging. However, the major translational barriers to CDs for imaging and sensing applications include synthetic strategies to obtain monodisperse CDs with tunable structural, electronic, and optical properties in order to achieve high-resolution deep-tissue imaging, intracellular detection, and sensing of metal ions with high sensitivity down to nanomolar levels. Herein, we report a novel strategy to synthesize and develop a multifunctional nitrogen-doped CDs probe of different sizes using a new combination of carbon and nitrogen sources.

Influence of charged defects on the interfacial bonding strength of tantalum- and silver-doped nanograined TiO.

A nano-grained layer including line defects was formed on the surface of a Ti alloy (Ti, Ti-6Al-4V ELI). Then, the micro- and nano-grained Ti with the formation of TiO on its top surface was coated with a bioactive Ta layer with or without incorporating an antibacterial agent of Ag that was manufactured by magnetron sputtering. Subsequently, the influence of the charged defects (the defects that can be electrically charged on the surface) on the interfacial bonding strength and hardness of the surface system was studied via an electronic model.

[Chinese medicinal culture in Tianmu Mountain before 1949].

According to the Annals of Western Tianmu Mountain, the medicinal plants in Tianmu Mountain reached as many as 1 200 types, with diversified species and excellent qualities, hence, the titles of "valuable thesaurus of Tianmu Mountain." The rich medicinal resources promotes the flourishing of local trading of crude medicines. From 1931 to 1940, based on the survey of the rural economy in Lin'an, Yuqian, and Changhua counties, there were 97 drugstores.

Usefulness of Deep Hypothermic Circulatory Arrest and Regional Cerebral Perfusion in Children.

To compare the safety and usefulness of deep hypothermic circulatory arrest (DHCA) and regional cerebral perfusion (RCP) during pediatric open heart surgery. Between January 1, 2004 and September 30, 2012, 1250 children with congenital cardiac defect underwent corrective operation with the DHCA or RCP technique in the Shanghai Children's Medical Center. Of them, 947 cases underwent the operation with the aid of DHCA (DHCA group), and 303 cases with RCP (RCP group).

Pulsatile flow improves cerebral blood flow in pediatric cardiopulmonary bypass.

The objective of this study was to evaluate the effect of pulsatile flow on cerebral blood flow (CBF) in infants with the use of a mild hypothermic cardiopulmonary bypass (CPB). Thirty infants scheduled for open heart surgery were randomized to the pulsatile group (Group P, n = 15) and nonpulsatile group (Group NP, n = 15). In Group P, pulsatile perfusion was applied during the aortic cross-clamping period, whereas nonpulsatile perfusion was used in Group NP.

Development of mechanical circulatory support devices in China.

Myocardial dysfunction leading to low cardiac output syndrome is a common clinical pathophysiological state. Currently, the use of mechanical circulatory support (MCS) is an essential aspect of the treatment of patients with cardiac failure. Several groups in China are engaged in the design and development of MCS devices.

[Application of spatial autocorrelation analysis to the COD, SO2 and TSP emission in Jiangsu province].

Spatial autocorrelation is an effective tool of spatial statistics, which is used to disclose the spatial structure of regional disparity. There are two different scales to measure regional spatial dependence: global spatial autocorrelation and local spatial autocorrelation. Based on environmental data of 13 cities in Jiangsu province from 1990 to 2006, the regional disparity of COD, SO2 and TSP emission was discussed by using spatial autocorrelation analysis methods.

[Analysis of primary elemental speciation distribution in mungbean during enzymatic hydrolization].

In the present paper, trace elements contents of cuprum, zincum, manganese and ferrum in mungbean and their primary speciation distribution during enzymatic hydrolization were investigated with ICP-AES OPTIMA 5300DV plasma emission spectroscopy. The trace elements were separated into two forms, i.e.

Effect of flow rate, negative pressure, and duration of modified ultrafiltration on hemodynamics and inflammatory mediators.

The objective of this study was to evaluate the effect of flow rate, negative pressure, and duration on modified ultrafiltration (MUF). Eighty children weighing less than 10 kg with congenital heart disease were randomly divided into four groups: group C (conventional MUF); group H (high flow rate MUF); group P (high negative pressure MUF); and group L (long duration, high flow rate MUF). The changes in body weight, hematocrit, and hemodynamics were recorded.

Left ventricular assist device for pediatric postcardiotomy cardiac failure.

Children with postcardiotomy heart failure who are unresponsive to maximal medical management have limited options for survival. Short-term mechanical circulatory support, such as with extracorporeal membrane oxygenation and ventricular assist devices, has assumed an expanding role in the care of these patients by providing a bridge to recovery. This report describes the use of left ventricular assist devices with centrifugal pumps in five pediatric cases (weight <15 kg) with postcardiotomy heart failure.

Seven years' experience of pediatric cardiopulmonary bypass: 8685 cases in Shanghai Children's Medical Center.

Herein we report our 7-year-experience of cardiopulmonary bypass. Between April 1, 1999, and December 31, 2005, 8685 children with congenital heart disease underwent cardiopulmonary bypass in Shanghai Children's Medical Center. The number of cases increased every year, and the number of patients younger than 1 year or weighing <10 kg also increased.

[The role of graded reoxygenation with cardiopulmonary bypass in prevention of reoxygenation injury and its safety].

Objective: To investigate the role of graded reoxygenation with cardiopulmonary bypass (CPB) in prevention of reoxygenation injury in children with cyanotic congenital heart defects, and to evaluate its safety.

Methods: Twenty pediatric patients with cyanotic congenital heart defect were randomly divided into 2 equal groups according to CPB methodology: group 1, undergoing routine hyperoxic CPB with CPB primed and initiated at FiO(2) of 1.0, and group 2 undergoing modified CPB with graded reoxygenation (CPB was primed and initiated at FiO(2) of 0.

[Investigation on Qiantang medical school].

Qiantang medical school came into being during the late Ming Dynasty and the early Qing Dynasty, and lasted for 200 years until Guang Xu Reign in the late Qing Dynasty. Lu Zhiyi and Zhang Suichen were the early representative figures; Zhang Zhicong, Zhang Xiju and Gao Shizong were the mid-period representative figures; and Zhong Xuelu was the late representative figure. They respected consistently the classics and the ancients, cultivated new talents, studied medical literature with a trinity of teaching, studying the classics and practising medicine as its characteristic.

[Arterial switch operation for transposition of the great arteries and double outlet of right ventricle with subpulmonary ventricular septum defect].

Objective: To summarize the clinical experience on the arterial switch operation for complex congenital heart disease in recent 3 years in our hospital.

Methods: Sixty-one patients with complex congenital heart disease received by arterial switch operation from Jan 2000 to May 2003. There were 26 patients with transposition of the great arteries and intact ventricular septum (TGA-IVS), 19 patients with transposition of the great arteries and ventricular septal defect (TGA-VSD) and 16 patients with double outlet of right ventricle with subpulmonary ventricular septum defect (Taussig-Bing).