Publications by authors named "De-Zhuang Huang"
Background: Hepatitis C virus (HCV) core antigen assays have been produced to exclude infectious donations collected during the preseroconversion window phase (PWP). For the same purpose, we evaluated the specificity and sensitivity of a novel hepatitis C virus NS3 antigen detection immunoassay and the application of this assay in clinical diagnosis.
Methods: Samples from 77 healthy subjects, 173 anti-HCV positive patients and 3708 hepatitis patients other than HCV positive were tested with the HCV NS3 antigen assay.
[Detection of HCV antigen in the serum by immunodotting].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
May 2006
Article Synopsis
- The study aims to develop a quick and effective method for early detection of Hepatitis C virus (HCV) infection.
- HRP-anti-HCV monoclonal antibodies were used to detect HCV antigens in blood samples, which showed varying positive rates among different patient groups.
- The new method proved to be highly specific and allows for effective early diagnosis and routine screening of HCV, comparable to existing testing methods.
Background: Regulated on activation, normal T-cell expressed and secreted (RANTES) plays a critical role in T-lymphocyte activation and proliferation. The process is involved in both acute and chronic phases of inflammation. The present study was to ascertain the possible correlations between chronic hepatitis B virus (HBV) infection and the RANTES gene polymorphisms and their expression.
View Article and Find Full Text PDFClinicopathological study on TTV infection in hepatitis of unknown etiology.
World J Gastroenterol
April 2002
Aim: To investigate the state of infection, replication site, pathogenicity and clinical significance of transfusion transmitted virus (TTV) in patients with hepatitis, especially in patients of unknown etiology.
Methods: Liver tissues taken from 136 cases of non-A non-G hepatitis were tested for TT virus antigen and nucleic acid by in situ hybridization (ISH) and nested-polymerase chain reaction (PCR). Among them, TT virus genome and its complemental strand were also detected in 24 cases of autopsy liver and extrahepatic tissues with ISH.