Publications by authors named "De-Xin Lei"
Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive lymphoma with a dismal prognosis, and novel therapeutic targets are urgently needed. Programmed death-ligand 1 (PD-L1) has become a promising therapeutic target for various cancers, but most of the studies have focused on expression of PD-L1 on tumor cells. Expression of PD-L1 on tumor-infiltrating non-malignant cells, especially monocytes, has not been studied in NKTCL, and its prognostic value remains unknown.
View Article and Find Full Text PDFPurpose: The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL.
Materials And Methods: From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12.
Article Synopsis
- The treatment strategy for Burkitt lymphoma (BL) has improved over the years, leading to better clinical outcomes, particularly in patients with limited-stage BL between 2002-2014 compared to 1983-2001.
- Analysis of the SEER database revealed a noteworthy increase in 5-year overall survival rates for limited-stage BL from 57.4% to 64.1% during the specified eras, but outcomes for elderly patients (60+) and young children (0-19) showed no significant improvement.
- Factors such as older age and being black were linked to lower survival rates, highlighting the need for more effective treatments and targeted therapies to enhance outcomes for elderly patients.
Background: Circulating Epstein-Barr virus (EBV) DNA concentrations were reported to have prognostic value for NK/T-cell lymphoma patients in limited small-scale studies. In this study, we aimed to evaluate the clinical utility of circulating EBV-DNA concentrations to a large sample of NK/T-cell lymphoma patients.
Methods: We conducted this meta-analysis, which included a total of 15 prospective and retrospective comparable studies to assess the association between pretreatment EBV-DNA (pre-DNA), posttreatment EBV-DNA (post-DNA), and clinical outcomes of NK/T-cell lymphoma patients.
Expressions and prognostic values of the transcription factors in human breast carcinoma.
Cancer Manag Res
September 2018
transcription factors () are a family of transcription factors involved in cell proliferation, differentiation, and apoptosis. Their important roles in the development and metastasis of breast carcinoma (BC) have been discovered by previous in vitro and in vivo studies. Yet, expressions and distinct prognostic values of these eight in human BC remain unclear in many respects.
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