Interaction of germanium analogue of organic isonitrile with Cu(I) imide in side-on mode.

[NHC → GeN(Ar)CuNAr], the formal adduct of germanium analogue of organic isonitrile [GeNAr] with Cu(I) imide [(CuNAr)] (Ar = 2,6-PrCH) was prepared from the N-heterocyclic carbene (NHC) stabilized acyclic germylene Ge[N(H)Ar] by reacting with two equivalents of BuLi and CuCl(PPh). As elucidated by X-ray crystal structural characterization, the two separated [GeNAr] moieties interacted with [(CuNAr)] core in the side-on mode.

Advanced BIFs with Co, B, N, and S for Electrocatalytic Oxygen Reduction and Oxygen Evolution Reactions.

In this work, a new alkaline-stable boron imidazolate framework () was rationally designed and successfully synthesized by solvothermal reaction. Due to its potential electrocatalytic active sites (Co, B, N, and S) and chemical stabilities, was explored as a bifunctional electrocatalyst toward electrochemical oxygen reactions, namely, oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). This work will open new avenues toward the design of stable, cheap, and more active BIFs as bifunctional catalysts.

Differential Surface Engineering Generates Core-Shell Porous Silicon Nanoparticles for Controlled and Targeted Delivery of an Anticancer Drug.

An approach to differentially modify the internal surface of porous silicon nanoparticles (pSiNPs) with hydrophobic dodecene and the external surface with antifouling poly--(2-hydroxypropyl) acrylamide (polyHPAm) as well as a cell-targeting peptide was developed. Specifically, to generate these core-shell pSiNPs, the interior surface of a porous silicon (pSi) film was hydrosilylated with 1-dodecene, followed by ultrasonication to create pSiNPs. The new external surfaces were modified by silanization with a polymerization initiator, and surface-initiated atom transfer radical polymerization was performed to introduce polyHPAm brushes.

Active Sites In Situ Implanted Hybrid Zeolitic Imidazolate Frameworks for a Water Oxidation Catalyst.

Metal-organic frameworks (MOFs) have been a focus of research because of their unique porous structure, but they are usually not directly for electrocatalysis. Herein, we prepared a special class of Fe/Zn/Mo-based trimetallic hybrid zeolitic imidazolate frameworks by in situ solvothermal synthesis that have the potential to act directly as highly efficient oxygen evolution reaction electrocatalysts. This work provides a foundation for the preparation of multimetal MOFs and expands the investigation of electrocatalysts.

Synthesis, Characterization, and Reaction of Digermylenes.

A series of digermylenes R(EGeL) (L=CH[C(Me)N(Ar)] , Ar=2,6-iPr C H ; E=O, R=1,3-C H (1), 1,4-C H (2), Me C(CH ) (3); E=NH, R=1,4-C H (4), 1,4-C H (5); E=C(O)O, R=1,3-C H (6)) were synthesized by the reactions of L'Ge (L'=HC[C(CH )N(Ar)]C(Me)N(Ar), Ar=2,6-iPr C H ) with selected diphenols, diol, diamines, and o-/m-phthalic acids, respectively. Treatment of digermylene 1,3-C H (OGeL) (1) with sulfur, selenium and CuX (X=Cl, Br, I) led to the formation of 1,3-C H [OGe(S)L] (8), 1,3-C H [OGe(Se)L] (9), and (CuX) [1,3-C H (OGeL) ] (X=Cl (10), Br (11), I (12)), respectively. The obtained products were characterized by melting point, elemental analysis, FT-IR, H and C NMR spectroscopy, and single-crystal X-ray diffraction.

Co-Heteroatom-Based MOFs for Bifunctional Electrocatalysts for Oxygen and Hydrogen Evolution Reactions.

Herein, a Co(II) heteroatom metal-organic framework was successfully post-modified via unsaturated coordinated S precisely capturing Ni on the surface of the porous structure. The newly pristine bimetallic MOFs have increasing active edge sites (Ni(II) and S), boosting electrocatalytic activity toward oxygen evolution reaction and hydrogen evolution reaction.

[Clinical outcome of tibiotalocalcaneal fusion using cannulated screw and humeral proximal locking plate inverted fixation through a lateral transfibular approach].

Objective: To evaluate the clinical outcome of tibiotalocalcaneal fusion using cannulated screw and humeral proximal locking plate inverted fixation through a lateral transfibular approach.

Methods: From June 2015 to December 2018, 15 patients underwent a tibiotalocalcaneal fusion operation using cannulated screw and inverted proximal humerus locking plate through a transfibular approach. There were 10 males and 5 females with the age ranging from 45 to 72 (58.

Porous silicon nanomaterials: recent advances in surface engineering for controlled drug-delivery applications.

Porous silicon (pSi) nanomaterials are increasingly attractive for biomedical applications due to their promising properties such as simple and feasible fabrication procedures, tunable morphology, versatile surface modification routes, biocompatibility and biodegradability. This review focuses on recent advances in surface modification of pSi for controlled drug delivery applications. A range of functionalization strategies and fabrication methods for pSi-polymer hybrids are summarized.

PLAC8 overexpression correlates with PD-L1 upregulation and acquired resistance to chemotherapies in gallbladder carcinoma.

Gallbladder carcinoma (GBC) is always diagnosed at an advanced stage, and patients often miss the opportunity for surgery. Gemcitabine (GEM) and platinum-based drugs, including oxaliplatin (OXA), are mainstays of chemotherapy. However, drug resistance causes treatment failure.

Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) ranks as the second most malignant type of primary liver cancer with a high degree of incidence and a very poor prognosis. Fat mass and obesity-associated protein (FTO) functions as an eraser of the RNA mA modification, but its roles in ICC tumorigenesis and development remain unknown. We showed here that the protein level of FTO was downregulated in clinical ICC samples and cell lines and that FTO expression was inversely correlated with the expression of CA19-9 and micro-vessel density (MVD).

Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications.

A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi films were first modified with 1-dodecene. To further modify the external surface of the pSi samples, an interlayer was applied by silanization with (3-aminopropyl)triethoxysilane (APTES) following air plasma treatment.

Kidney-Replenishing Herb Induces SOCS-3 Expression via ERK/MAPK Pathway and Improves Growth of the First-Trimester Human Trophoblast Cells.

Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage. Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts. In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells.

Facile Synthesis of Metal-Loaded Porous Carbon Thin Films via Carbonization of Surface-Mounted Metal-Organic Frameworks.

We report a facile approach to prepare metal-nanocatalyst-incorporated carbon thin films with uniform size distribution via carbonization of surface-mounted metal-organic frameworks (SURMOFs) and metal oxo-clusters loaded SURMOF. The calcinated thin films have high performance of methylene blue degradation and the reduction of nitrobenzene. This study describes a general strategy for preparing various nanoparticle-impregnated porous carbon thin films for applications in catalysis.

A Chiral 3 D Net with 2 D Cairo Pentagonal Tiling Projection in Site-Modified CuCN/CuSCN Networks.

A novel isohedral 3-periodic net (i.e. a net with one kind of tile), showing a Cairo pentagonal tiling projection on the Euclidean plane, has been identified in a series of site-modified CuCN/CuSCN networks, namely, [Cu (SCN) (CN) ⋅Ni(tpy) ] (1), [Cu (SCN)(CN) ⋅Ni(tpy) ] (2) and [Cu (CN) ⋅Ni(tpy) ] (3) (tpy=2,2':6'',2''-terpyridine).

Fullerene-like Polyoxotitanium Cage with High Solution Stability.

We present the formation of the largest titanium-oxo cluster, [Ti42(μ3-O)60(OiPr)42(OH)12)](6-), with the first fullerene-like Ti-O shell structure. The {Ti42O60} core of this compound exemplifies the same icosahedral (Ih) symmetry as C60, the highest possible symmetry for molecules. According to the coordination environments, the Ti centers in this cluster can be arranged into a Platonic {Ti12} icosahedron and an Archimedean {Ti30} icosidodecahedron.

Synthesis of borocarbonitride from a multifunctional Cu(I) boron imidazolate framework.

A functional Cu(I) boron imidazolate framework (BIF) with a ladder-chain structure can not only change to another single-chain structure by incorporating 4,4'-bipyridine, but can also act as a reducing agent to load trimetal Au-Ag-Pd nanoparticles directly; the BIF with loaded noble NPs showed an excellent reduction effect on 4-nitrophenol. Moreover, we obtained a porous borocarbonitride by the direct carbonisation of this low-dimensional BIF. The resulting porous borocarbonitride exhibits fast adsorption behavior for 4-nitrophenol and can be a high-temperature conductor.

A Rational Strategy To Construct a Neutral Boron Imidazolate Framework with Encapsulated Small-Size Au-Pd Nanoparticles for Catalysis.

A series of 3D neutral boron imidazolate frameworks (BIFs) with octahedral metal centers were synthesized based on the charge-balancing principle. Au-Pd nanoparticles (NPs) with a mean size of 2.12 nm were then successfully obtained and encapsulated in these BIF structures through the simultaneous reduction of Au(3+)/Pd(3+) ions by B-H bonds of tridentate boron ligands.

Targeted design of a cubic boron imidazolate cage with sensing and reducing functions.

A cubic cationic cage is rationally designed by using tridentate boron-imidazolate ligands to link tetrahedral metal Zn(ii) centers, which displays excellent properties in the Cr2O7(2-) exchange and can reduce Au(3+) ions into Au nanoparticles directly.

Facile synthesis of bimetal Au-Ag nanoparticles in a Cu(I) boron imidazolate framework with mechanochromic properties.

A Cu(I) boron imidazolate framework with 2-fold interpenetrating ths topology shows luminescent mechanochromism, and it can directly reduce bimetal Au-Ag nanoparticles into its structure, leading to catalytic applications.

Redox-active Cu(I) boron imidazolate framework for mechanochromic and catalytic applications.

A redox-active Cu(I) boron imidazolate framework with ladder-chain structure shows mechanochromic luminescence and can directly reduce Ag nanoparticles into its structure, due to the presence of rich B-H functional bonds in the structure.

Luminescent mechanochromic porous coordination polymers.

Three 2D luminescent isomeric porous coordination polymers are synthesized and characterized. Their luminescence properties can be modified by grinding and they can act as mechanochromic materials and their properties are probably related to the weak interactions of cuprophilicity and π-π interactions.

A multifunctional helical Cu(I) coordination polymer with mechanochromic, sensing and photocatalytic properties.

A multifunctional Cu(I) coordination polymer constructed from helical chains showed unusual mechanochromic, sensing of nitrobenzene and photocatalytic properties on degradation of organic dyes.

Two-dimensional copper(I) coordination polymer materials as photocatalysts for the degradation of organic dyes.

Two isomeric two-dimensional copper(I) coordination polymer materials based on an in situ generated 5-(3-pyridyl)tetrazole ligand show similar layer structures but distinct photoluminescent and photocatalytic properties, which present an interesting comparative study on the structure-property correlation between isomeric materials.

Prognostic factors in patients with pancreatic cancer.

The identification of prognostic factors for pancreatic cancer patients could provide insightful information for their management in the clinic. A total of 302 pancreatic cancer patients were enrolled in this study. The clinicopathological characteristics, treatment selection and laboratory test data were retrospectively retrieved from the medical records and follow-up data were obtained via telephone interview.