Publications by authors named "De-Wen Bi"
Article Synopsis
- - Four new diterpenoids (1-4) and sixteen known ones (5-20) were extracted from the plant Euphorbia helioscopia L., with compounds 1 and 2 categorized as rhamofolane, compound 3 as lathyranes, and compound 4 as jathophanes.
- - The isolated compounds were evaluated for their cytotoxicity and efficacy against the Zika virus, with compounds 9 and 15 demonstrating low cytotoxicity and high anti-Zika activity (EC values of 2.63 and 5.94 μM, respectively).
- - Researchers further assessed the inhibitory effects of these compounds on protein levels using techniques like Western blotting and immunof
Three new lanostane triterpenoids () along with two new amides fatty compounds () were isolated from the ethyl acetate extract of a culture of the endophytic fungus gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds were evaluated for their anti-inflammatory and tyrosinase inhibition activities.
View Article and Find Full Text PDFTwo new compounds, including a norsesquiterpenoid, annuionone H (), and a quassinoid, picraqualide G (), along with eleven known compounds (), were isolated from the twigs and leaves of . Comprehensive spectroscopic analyses and NMR calculation with DP4+ analysis were used to identify their structures. Moreover, of all these compounds, compound showed a week inhibition rate in the anti-inflammatory screening results against mouse macrophage J774A.
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- Five new labdane diterpenoids (Stevelins A-E) and three known labdane diterpenoids were identified from the plant Stevia rebaudiana.
- The structures of these compounds were determined using NMR spectroscopy, high-resolution mass spectrometry, and X-ray crystallography, with additional insights from electronic circular dichroism calculations.
- Most of the isolated compounds showed significant effects in inhibiting foam cell formation induced by oxidized low-density lipoprotein, indicating their potential as treatments for atherosclerosis.
Article Synopsis
- * Their structures were determined using advanced spectroscopic data and methods like DP4+ analysis for relative configurations and quantum chemical calculations for absolute configurations.
- * Certain compounds (1, 3, 5, 9, 10, 12, 15, 16, and 19) exhibited significant inhibitory effects on NLRP3 inflammasome activation, and compound 10 specifically reduced IL-1β secretion and blocked macrophage pyroptosis in lab tests.
Article Synopsis
- Two new clerodane norditerpenoids, named Callintegers A and B, were discovered featuring a unique 6/6/6-fused tricyclic ring system.
- Their structures and configurations were confirmed using advanced techniques like quantum chemical calculations and X-ray diffraction.
- Compound B was found to inhibit IL-1β secretion effectively, suggesting it disrupts NLRP3 inflammasome activation, with a notable IC value of 5.5 ± 3.2 μM.
Two new compounds verboncin A () and verboncin B () and 14 known compounds ( and ) were isolated from , and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the results were compared with literature values. The absolute configuration of was determined by calculating electronic circular dichroism (ECD).
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- * Scientists used techniques like 1D and 2D-NMR spectroscopy and high-resolution mass spectrometry to identify and understand the structure of these compounds.
- * Among the compounds tested for anti-inflammatory effects, one known as compound 15 showed significant activity by reducing LDH levels in a dose-dependent manner, with an IC value of 2.89 μM.
Article Synopsis
- Three new compounds called Callicarpnoids A-C were discovered from the stems of Callicarpa arborea, and their structures were determined using advanced techniques like spectroscopic analysis and X-ray diffraction.
- Compounds 2 and 3 showed strong anti-cancer activity against breast and colorectal cancer cells, with effective concentrations ranging from 5.2 to 7.2 μM that were comparable to existing treatments.
- Analysis of protein levels indicated that these compounds promote cancer cell death (apoptosis) by increasing certain proteins (like Bax) and decreasing others (like caspases), suggesting they work through multiple pathways to induce apoptosis.
Article Synopsis
- - Six new sesquiterpenoids (ainslides A-F) were identified and isolated from the plant Ainsliaea pertyoides, along with eight previously known compounds.
- - The structures of these compounds were determined using advanced techniques like NMR, mass spectrometry, UV, IR spectroscopy, and X-ray diffraction.
- - The anti-inflammatory potential of these compounds was tested, revealing that several, particularly compounds 3 and 7-13, effectively inhibit the NLRP3 inflammasome with IC values ranging from 1.80 to 4.33 μM.
Article Synopsis
- A phytochemical study of Euphorbia helioscopia led to the discovery of thirteen compounds, including nine new diterpenoids named Euphzycopias A - I (1-9).
- The structures of compounds 1-4 feature unique cyclic systems, with compound 1-3 having 5/7/6 arrangements and compound 4 displaying a more complex 4/11 polycyclic structure.
- Testing on NLRP3 inflammasomes showed that the diterpenes isolated from E. helioscopia exhibited significant inhibitory effects, with IC values ranging from 3.34 to 14.92 μM.
Article Synopsis
- Four new diterpenoids, named rubellawus A-D, were discovered in the flowers of the plant Callicarpa rubella, along with three previously known compounds.
- The chemical structures of these compounds were determined using different spectroscopic techniques.
- The compounds were tested for anti-inflammatory properties, and two specific acids showed notable inhibitory effects on the NLRP3 inflammasome, making them potential candidates for further research.
Article Synopsis
- Callicarpins A-D feature a unique A--clerodane structure with a bicyclo[5.4.0]undecane ring, while callicarpins E-G have a 5/6-fused -clerodane diterpenoid skeleton, both isolated from specific sources.
- Their chemical structures were determined using advanced methods including spectroscopy, X-ray crystal diffraction, and electronic circular dichroism (ECD) analysis.
- Compounds demonstrated strong inhibition of the NLRP3 inflammasome, effectively preventing pyroptosis by inhibiting Casp-1 activation and IL-1β secretion in certain immune cells.
Article Synopsis
- Caesalpinnone A is a unique compound with a hybrid structure combining features of flavan and chalcone, found in the plant Caesalpinia enneaphylla.
- Three new compounds, caesalpinflavans A-C, were also discovered along with Caesalpinnone A from the same plant.
- Caesalpinnone A demonstrated significant cytotoxicity against several human tumor cell lines, with effective concentration values (IC) between 0.54-0.87 μM.