Publications by authors named "De-Tian Wang"
Background: The mammalian target of rapamycin (mTOR) pathway, a key cellular signaling pathway associated with various cellular functions, has distinct roles in the inflammatory process. In this study, the mTOR inhibitor rapamycin (Rapa) was used to test whether inhibition of mTOR activation attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a murine model.
Methods: Mice pretreated with Rapa or vehicle were given LPS intratracheally.
Article Synopsis
- The study aimed to detect HPV 16/18 infections in patients with head and neck squamous cell carcinoma and investigate their association with Ki-67 and P53 protein expressions in tumors.
- HPV 16/18 DNA was found in 62.8% of patients, and while Ki-67 showed variable expression, P53 was present in 46.15% of cases, indicating a potential link between HPV infection and tumor characteristics.
- The findings suggest that HPV 16/18 might contribute to the cancer's development, particularly through abnormal P53 protein expression, while no significant correlations were found with demographic factors or Ki-67 levels.
[Lymph node image with ultrasmall superparamagnetic iron oxide and comparison with pathological result].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
April 2009
Objective: To assess the characteristics of enhanced magnetic resonance image with ultrasmall superparamagnetic iron oxide (USPIO) in the inflammatory and tumor metastatic rabbit model, and explore its relevance with histologic ultrastructural findings.
Methods: Totally 36 New Zealand white rabbits were randomly divided into lymphadenitis group and metastatic group. Complete Freund's adjuvant was injected into the bilateral dorsal footpads of 18 rabbits to set up ipsilateral lymphadenitis model.
Article Synopsis
- The study focused on eight Chinese patients with hepatosplenic gammadelta T-cell lymphoma to explore their clinical and pathological features, as well as their immunophenotype and TCR gene rearrangements.
- The patients exhibited enlarged spleens with histological infiltration by lymphoma cells, and immunohistochemical staining showed consistent expression of CD3, CD43, and CD56, with some cases also expressing CD8 and none expressing CD4.
- Notably, the findings suggest that while the characteristics of this lymphoma type align with previous data, splenomegaly was less extreme in these patients, and a positive CD8 status was observed.
[Morphological study of severe acute respiratory syndrome (SARS)].
Zhonghua Bing Li Xue Za Zhi
December 2003
Objective: Seven cases of autopsy from SARS patients are studied to investigate the pathogenesis and the pathologic changes of the major organs.
Methods: Detailed gross and microscopic examination of the autopsy specimen is performed, including lung, heart, liver, kidney, spleen and lymph nodes.
Results: All of the lungs are markedly enlarged and consolidated.
[Immunohistochemical investigation of lungs with severe acute respiratory syndrome].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
October 2003
Objective: To investigate the roles of different cells in the pulmonary lesions in the severe acute respiratory syndrome (SARS) patients.
Methods: The monoclonal antibodies of CD8, CD20, CD34, LCA, CD56, CD68, and AE1/AE3 are used to demonstrate the different cells in the lung specimens of SARS patients in order to study the patterns of cell responses in this new disease. Meanwhile the HE stained slides were also carefully studied to compare with the results of immunohistochemical staining.
[Lung pathology of severe acute respiratory syndrome].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
June 2003
Objective: To study the morphological features of the lungs obtained from autopsies of severe acute respiratory syndrome (SARS) patients.
Methods: Bilateral lungs from 7 patients died from SARS were carefully studied grossly and microscopically. All tissues from these cases were routinely processed and carefully studied.