LPS induces activation of the TLR4 pathway in fibroblasts and promotes skin scar formation through collagen I and TGF-β in skin lesions.

Hypertrophic scars are proliferative diseases of dermal fibroblasts that produce abundant amounts of collagen and extracellular matrix in the skin after severe burns, inflammation and trauma. Hypertrophic scars affect the daily life of patients and cause a series of problems. The biological mechanism of hypertrophic scar formation is still unclear and has received much attention in plastic surgery.