One new 12, 8-guaianolide sesquiterpene lactone with antihyperglycemic activity from the roots of .

Three 12, 8-guaianolide sesquiterpene lactones, including a new compound intybusin F (), and a new natural product cichoriolide I (), along with six known 12, 6-guaianolide compounds (-) were isolated from the roots of L. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of new compounds were elucidated based on analysis of the experimental and calculated electronic circular dichroism spectra.