Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer.

Background: Alpha-fetoprotein (AFP) is one of the diagnostic standards for primary liver cancer (PLC); however, AFP exhibits insufficient sensitivity and specificity for diagnosing PLC.

Aim: To evaluate the effects of high-risk factors and the diagnostic value of AFP in stratified PLC.

Methods: In total, 289 PLC cases from 2013 to 2019 were selected for analysis.

Glutamine deprivation impairs function of infiltrating CD8 T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis.

Background: The functions of infiltrating CD8 T cells are often impaired due to tumor cells causing nutrient deprivation in the tumor microenvironment. Thus, the mechanisms of CD8 T cell dysfunction have become a hot research topic, and there is increased interest on how changes in metabolomics correlate with CD8 T cell dysfunction.

Aim: To investigate whether and how glutamine metabolism affects the function of infiltrating CD8 T cells in hepatocellular carcinoma.

Nomogram Incorporating the WNT/β-Catenin Signaling Pathway for Predicting the Survival of Cutaneous Melanoma.

Background: Accurate prediction of the survival of cutaneous melanoma (CM) permits the selection of the optimal treatment. Currently, the TNM stage has limitations in predicting the survival of CM. There is evidence that the WNT/β-catenin signaling pathway has the potential to predict the CM prognosis.

Differences in shotgun protein expression profile between superficial bladder transitional cell carcinoma and normal urothelium.

This study was undertaken to identify differences in protein expression profiles between superficial bladder transitional cell carcinoma (BTCC) and normal urothelial cells. We used laser capture microdissection (LCM) to harvest purified cells, and used two-dimensional liquid chromatography (2D-LC) followed by electrospray ionization-tandem mass spectrometry (ESI-MS/MS) to separate and identify the peptide mixture. A total of 440/438 proteins commonly appeared in 4 paired specimens.

Quantitative risk stratification and individual comprehensive therapy for invasive bladder cancers in China.

Background: To evaluate the risk factors for invasive bladder cancer and to develop a predictive model for the improvement of individual comprehensive therapy for invasive bladder cancers.

Materials And Methods: The records of 356 patients with invasive bladder cancer, operated on at three Chinese medical institutes, were reviewed. The Cox proportional hazards regression model was used to assess the clinical and pathological variables affecting disease-free survival (DFS).