[Significance of the mitochondrial D-loop alterations in hyperplastic pancreatic ductal cells in the vicinity of pancreatic cancer coexisting with chronic pancreatitis].

Objective: To explore the significance of mitochondrial D-loop alterations in hyperplastic pancreatic ductal cells in vicinity of pancreatic cancer coexisting with chronic pancreatitis.

Methods: Malignant lesions and foci of pancreatic ductal intraepithelial neoplasia of the pancreas and paired normal gastric mucosal epithelial cells from the same patients, respectively, were assessed by polymerase chain reaction. Somatic point mutations and sequence variants of D-loop were searched by direct sequencing of the mitochondrial genome.

[To inquiry into clinical-pathological factors influencing cytological accuracy of pancreatic head lesions].

Objective: To inquiry into clinical-pathological factors influencing cytological accuracy of pancreatic head lesions.

Methods: Cytology was retrospectively evaluated in 94 inpatients with a mass in head of pancreas existing with chronic pancreatitis in the past decade, the results of cytology were compared with clinical pathology or clinical follow-up to estimate the value and accuracy of cytology in detecting pancreatic cancer. Pancreatic clinical-pathology includes size of mass and component of mass which was composed of cancerous mode of development including shape of conglomeration, nest and pervasion, and pancreatic ductal epithelium inside the vicinity of 1 cm around the mass.

Extended radical operation of pancreatic head cancer: appraisal of its clinical significance.

Aim: To evaluate the significance of extended radical operation and its indications.

Methods: Between January 1995 and December 1998, 56 inpatients with pancreatic head cancer received operation. Among them 35 patients (group 1) experienced the Whipple operation, and 21 patients (group 2) received the extended radical operation.

[Significance of extended radical resection for cancer of pancreatic head].

Objective: To evaluate the significance of extended radical resection in the treatment of pancreatic head cancer and its indication.

Methods: Between Jan. 1995 and Dec.

Risk factors influencing recurrence following resection of pancreatic head cancer.

Aim: Whether operative procedure is a risk factor influencing recurrence following resection of carcinoma in the head of pancreas or not remains controversies. In this text we compared the recurrence rate of two operative procedure: the Whipple procedure and extended radical operation, and inquired into the factors influencing recurrence after radical resection.

Methods: From January 1995 to December 1998, 35 cases of carcinoma of pancreas underwent the Whipple operadure, 21 patients received the Extended radical operation.

Significance of perigastric lymph node involvement in periampullary malignant tumor.

Aim: To determine the perigastric lymph node involvement in periampullar tumors, in an attempt to optimize the surgical treatment of pylorus- preserving pancreatoduodenectomy.

Methods: We retrospectively investigated the frequence of lymph nodes involvement in perigastric regions. Distribution and number of involved lymph nodes were examined from 112 patients with carcinoma of pancreas, 59 patients with distal bile duct carcinoma, and 41 patients with carcinoma of the papilla of Vater.

Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.

Aim: To summarize progress in the study of K-ras gene studies in pancreatic cancer and its potential clinical significance in screening test for early detection of pancreatic cancer, and to differentiate pancreatic cancer from chronic pancreatitis in recent decade.

Methods: Literature search (MEDLINE 1986-2003) was performed using the key words K-ras gene, pancreatic cancer, chronic pancreatitis, and diagnosis. Two kind of opposite points of view on the significance of K-ras gene in detection early pancreatic cancer and differentiation pancreatic cancer from chronic pancreatitis were investigated.

[Inquire into factors influencing recurrence following resection of carcinoma of the head of pancreas].

Objective: Inquire into factors influencing recurrence following resection of carcinoma of the head of pancreas to raise survival rate of pancreatic cancer.

Methods: We performed a retrospective review of 56 pancreatic resections with carcinoma of the head of pancreas operated from January 1995 to December 1998. 35 patients tolerated the Whipple operadure in comparison with 21 patients received the extended radical operation contemporaneously.

p53 protein expression and CA19.9 values in differential cytological diagnosis of pancreatic cancer complicated with chronic pancreatitis and chronic pancreatitis.

Aim: To evaluate p53 protein overexpression and to measure serum CA19.9 concentrations in cytological diagnosis of patients with suspected pancreatic cancer.

Methods: 24 patients with suspected pancreatic cancer due to chronic pancreatitis, had a pancreatic mass determined by imaging methods.

Surgical management of transected injury to the pancreatic neck.

Objective: To present a batch of data of transected pancreatic neck injuries and to sum up the experience in surgical interventions for the injuries.

Methods: We analysed 13 patients with a transected injury to the pancreatic neck from Jan. 1995 to Dec.