Publications by authors named "De-Qiao Sheng"
Article Synopsis
- - Lung cancer is the most common cause of cancer deaths globally, and its development involves a complex interaction of genetic, environmental, and epigenetic factors.
- - Key epigenetic mechanisms, such as DNA methylation and noncoding RNAs, play crucial roles in tumorigenesis by affecting important biological processes and signaling pathways.
- - Research into epigenetic changes not only enhances our understanding of how lung cancer develops but also offers potential for developing biomarkers for early diagnosis, prognosis, and targeted therapies.
A negative regulatory element-dependent inhibitory role of ITF2B on IL-2 receptor alpha gene.
Biochem Biophys Res Commun
October 2005
Despite the fact that the negative regulatory element (NRE) within the upstream regulatory region of human IL-2 receptor alpha (IL-2Ralpha) gene has been identified two decades ago, mechanisms of the NRE function on the gene are hitherto unknown. In this paper, we report for the first time that the immunoglobulin transcription factor 2B (ITF2B) encoded by transcription factor 4 (TCF4) gene is a NRE binding protein. The full-length TCF4 cDNA clone was obtained from a HTLV-1 transformed human peripheral T cell MACHERMAKER cDNA library with NRE as the bait in yeast one-hybrid system.
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