Publications by authors named "De-Li Tan"
Article Synopsis
- Crosstalk between cancer-associated fibroblasts (CAFs) and hepatocellular carcinoma (HCC) cells is critical for tumor growth, as CAFs secrete factors that promote cancer cell proliferation and survival.
- In this study, it was found that CAFs enhance HCC cell growth by producing interleukin-6 (IL-6), which then stimulates the production of insulin-like growth factor-1 (IGF-1) in HCC cells, leading to increased tumor progression and resistance to chemotherapy.
- Inhibiting the IGF-1 receptor with NT157 not only counteracted the effects of CAF-derived IL-6 and IGF-1 but also improved the effectiveness of sorafenib, a common
Systematic interrogation of tumor-infiltrating immune cells (TIICs) is key to the prediction of clinical outcome and development of immunotherapies. However, little is known about the TIICs of hepatocellular carcinoma (HCC) and its impact on the prognosis of patients and potential for immunotherapy. We applied CIBERSORT of 1090 tumors to infer the infiltration of 22 subsets of TIICs using gene expression data.
View Article and Find Full Text PDFThe short isoform of Rho guanine nucleotide exchange factor ARHGEF5 is known as TIM, which plays diverse roles in, for example, tumorigenesis, neuronal development and Src-induced podosome formation through the activation of its substrates, the Rho family of GTPases. The activation is auto-inhibited by a putative helix N-terminal to the DH domain of TIM, which is stabilized by the intramolecular interaction of C-terminal SH3 domain with a poly-proline sequence between the putative helix and the DH domain. In this study, we systematically investigated the structural basis, energetic landscape and biological implication underlying TIM auto-inhibition by using atomistic molecular dynamics simulations and binding free energy analysis.
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