Publications by authors named "De-Jun Kong"

Article Synopsis
  • Allograft rejection is a significant challenge in organ transplantation, and this study investigates the effects of recombinant human IL-37 (rhIL-37) in improving graft survival in a mouse model.
  • The research found that rhIL-37 treatment led to long-term acceptance of transplanted hearts by reducing immune cell infiltration and modulating cytokine profiles, specifically increasing Treg cells and decreasing inflammatory cytokines like TNF-α.
  • The findings suggest that IL-37 may be a promising therapeutic option for preventing organ rejection, highlighting its role in immune regulation through pathways like p-mTOR.
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Strain KC 927 was isolated during an investigation of the soil bacteria diversity on Jiaozi Mountain, central Yunnan, Southwest China. The strain was Gram-stain-negative, rod-shaped, non-motile, oxidase-negative, catalase-positive and aerobic. Results of 16S rRNA gene alignment and phylogenetic analysis indicated that strain KC 927 was a member of the genus and closely related to GCR10 (98.

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Background: Capecitabine (CAP) is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation (LT) in clinical studies. Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy mice. Ferroptosis, a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation, is an important mechanism by which CAP induces cell death.

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We investigated potassium (K) accumulation characteristics and expression of K metabolism related genes in one high-K variety (ND202) and a common variety (NC89) of tobacco (Nicotiana tabacum L.). Results showed that K accumulation and leaf K content in ND202 were higher than those in NC89.

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Article Synopsis
  • The study focuses on the genome of the medicinal leech Whitmania pigra, revealing a genome size of 177 Mbp with 26,743 predicted protein-coding genes.
  • Comparative genomic analysis shows significant gene similarities between W. pigra and other leech species, Hirudo medicinalis and Helobdella robusta, including unique gene families and a new hirudin gene variant.
  • The findings enhance understanding of the genetic diversity and bioactive compounds in leeches, providing valuable insights for medicinal applications.
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Objective: This study aimed to discover the ceRNAs network in the pathophysiological development of human colorectal cancer (CRC) and to screen biomarkers for target therapy and prognosis by using integrated bioinformatics analysis.

Methods: Data on gene expressions of mRNAs, miRNAs, and circRNAs and clinical information were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases, respectively. Differentially expressed mRNAs (DEmRNAs) were identified by using the DESeq2 package of R software.

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Organ transplantation is an effective treatment strategy for patients with irreversible organ failure or congenital organ dysfunction. Oxymatrine (OMT) is a quinolizidine alkaloid with protective and anti-inflammatory effects on tissues and organs. The objective of this study was to investigate whether OMT could exert protective effects in cardiac allografts by regulating immune cells.

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Article Synopsis
  • Chronic allograft vasculopathy (CAV) is a significant issue in transplant survival, with various complicated mechanisms hindering effective treatments.
  • The study investigates the combined effects of melatonin (MT) and mesenchymal stromal cells (MSCs) on mitigating CAV in a mouse model of aorta transplantation.
  • Results indicate that the MT and MSC combination significantly reduces CAV-related pathological changes and alters immune cell infiltration, promoting a healthier immune response by increasing regulatory T cells (Tregs) while inhibiting other T cell populations.
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To evaluate and compare the short-term outcomes of robotic surgery and laparoscopic approach in distal pancreatectomy (DP). EMBASE, PubMed, the Cochrane Library, CNKI and Wan Fang database were retrieved from the inception of electronic databases to June 2019. All analyses were performed using Stata/SE 15.

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The green peafowl () is one of the most threatened pheasants in the world. In China, it is widely appreciated for its beauty as well as historical and cultural value, but current populations number less than 500 individuals. Recently, Tang and colleagues reported in that the green peafowl is likely to become extinct due to the construction of the Jiasajiang Level 1 Hydropower Station within the Red River Upstream District (RRUD) and thus called for a stop to this project (Tang et al.

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From November 2009 to April 2010, roosting-site characteristics of black-necked cranes (Grus nigricollis) were observed at Napahai Provincial Nature Reserve, Shangri-La, Yunnan, China. The positions of roosting-sites were determined by triangulation with markers and field correction. All of the 63 roosting-sites observed were located in patchy marshes with water, which contained some mud on the bottom and 81% of the roosting-sites were covered by plants.

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Objective: To study the clinical effect of Chinese drugs administered by both oral intake and retention enema on inflammatory bowel diseases (IBD).

Methods: Adopting a randomized controlled design, 78 patients were assigned to three groups: 26 patients in group A treated with Chinese drugs given by both oral intake and retention enema, 27 in group B with Chinese drugs given by retention enema only, and 25 in group C with given Western medicine. The changes before and after a 30-day treatment of the patients' symptoms (including diarrhea, abdominal pain, mucous or pus-bloody stool), colonoscopic examination scores and histopathology of the colonic membrane were observed.

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