Publications by authors named "De-Jiu Kong"
Article Synopsis
- The study aimed to evaluate how effective cell-free DNA assays are in diagnosing bladder cancer by analyzing multiple related studies.
- A total of 11 studies involving 802 bladder cancer patients and 668 controls were assessed, revealing an overall sensitivity of 71% and specificity of 78%.
- The findings suggest that cell-free DNA testing is a reliable diagnostic tool for bladder cancer, with no significant publication bias affecting the results.
The prognosis of esophageal squamous cell carcinoma is poor. We hereby presented a highly integrated and clinically relevant precision nanomedicine strategy to target ESCC molecularly and physically for significant improvement of the treatment efficacy. We firstly identified PI3K overexpression in patient samples and its relation to poor patient survival.
View Article and Find Full Text PDFAim: This study aims to develop new nanoformulations of EGFR T790M targeted inhibitor AZD9291 and paclitaxel (PTX) for combination therapy of lung cancer.
Materials & Methods: We prepared and characterized PTX- and AZD9291-loaded disulfide cross-linking micelles (DCMs), and evaluate their combination effect and toxicity in vitro and in lung cancer-bearing mice.
Results: Drug-loaded DCMs were relatively small in size, and possessed glutathione-responsive drug release.
One of the major goals of precision oncology is to promote combination therapy to improve efficacy and reduce side effects of anti-cancer drugs based on their molecular mechanisms. In this study, we aimed to develop and validate new nanoformulations of docetaxel (DTX) and bortezomib (BTZ) for targeted combination therapy to treat human esophageal cancer. By leveraging our versatile disulfide cross-linked micelles (DCMs) platform, we developed nanoformulations of DTX and BTZ (named DTX-DCMs and BTZ-DCMs).
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