Publications by authors named "De-Hua Zeng"
Lung adenocarcinoma (LUAD) is a study that examines the prognostic value of lactate metabolism genes in tumor cells, which are associated with clinical prognosis. We analyzed the expression and clinical data for LUAD from The Cancer Genome Atlas database, using the GSE68465 dataset from the Gene Expression Omnibus and the MSigDB database. LASSO Cox regression and stepwise Cox regression were used to identify the optimal lactate metabolism gene signature.
View Article and Find Full Text PDFArticle Synopsis
- Lung adenocarcinoma (LUAD) exhibits diverse tumor types, and this research aims to identify its subtypes and create a reliable prognostic model based on gene activity changes.* -
- Utilizing data from The Cancer Genome Atlas (TCGA), researchers analyzed gene activity to identify prognosis-related differential gene sets and established a prognostic risk score (RS) model and nomogram for predicting patient outcomes.* -
- The study identified two LUAD subtypes, with Cluster 2 showing a poorer prognosis; the developed prognostic signature effectively predicts survival and can guide personalized treatment strategies for patients.*
Ischemic stroke (IS) has become a cerebrovascular disease of widespread concern. Overexpression of circUCK2 alleviates neuronal damage in IS. However, the specific regulatory mechanisms of circUCK2 are not fully understood.
View Article and Find Full Text PDFIntrahepatic cholangiocarcinoma is a relatively uncommon malignant neoplasm. We recently encountered an unusual case of intrahepatic cholangiocarcinoma that histologically resembled a thyroid carcinoma. A thorough review of the English literature revealed only 2 similar cases that have been previously reported.
View Article and Find Full Text PDFAims: We retrospectively analyzed clinicopathologic features of 8 cases of hepatitis B virus-associated glomerulonephritis with hyaline thrombi, to confirm the diagnosis of cryoglobulinemic glomerulonephritis (CRYGN) associated with HBV infection.
Methods: Retrospective analysis was carried out with demographic information, clinical manifestations, laboratory parameters, pathological and prognostic features.
Results: The median age of 8 patients was 30.