Thyroid dysfunction in nonvalvular atrial fibrillation and clinical outcomes.

Background: Thyroid dysfunction's effects on those who have been diagnosed with atrial fibrillation have not been well investigated. We looked at how thyroid function among patients with pre-existing atrial fibrillation related to thromboembolic risk and clinical outcomes.

Methods: We gathered the medical information of patients diagnosed with nonvalvular atrial fibrillation (NVAF) between 2016 and 2020 at Dongguan People's Hospital.

A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.

CRYPTOCHROME-INTERACTING basic helix-loop-helix 1 (CIB1) is a well characterized transcriptional factor which promotes flowering through the physical interaction with the blue light receptor CRYPTOCHROME 2 (CRY2) in Arabidopsis. However, the role of its counterpart in crop species remains largely unknown. Here, we describe the isolation and characterization of a CIB1 homolog gene, Glycine max CIB1-LIKE10 (GmCIL10), from soybean genome.

MicroRNA alterations in senescent endothelial progenitor cells induced by remnant-like lipoproteins.

Background: Remnant-like lipoproteins (RLPs) have been demonstrated to accelerate the onset of endothelial progenitor cells (EPCs) senescence. Recent study has determined that microRNAs (miRNAs) were closely associated with cellular proliferation and senescence. This study aimed to examine whether RLPs lead to an alteration of miRNAs in senescent EPCs.

Remnant-like lipoproteins may accelerate endothelial progenitor cells senescence through inhibiting telomerase activity via the reactive oxygen species-dependent pathway.

Background: We previously found that remnant-like lipoproteins (RLPs), lipolytic products of triglyceride-rich lipoproteins including very low-density lipoprotein and chylomicron, can accelerate endothelial progenitor cell (EPC) senescence, which involves telomerase activity. The aim of this study was to investigate the effects of RLPs on telomerase activity and the catalytic subunit telomerase reverse transcriptase (TERT) in EPCs and the associated signal pathway.

Methods: RLPs were prepared from plasma samples by the immunoaffinity method.

Interaction between remnant-like lipoprotein particles and adipocytes.

Inflammation plays a pivotal role in the pathophysiology of atherosclerosis. Remnant-like lipoprotein particles (RLPs) have been implicated as potentially atherogenic lipoproteins. RLPs can induce a pronounced inflammatory response especially during the postprandial phase.

Remnant-like particles accelerate endothelial progenitor cells senescence and induce cellular dysfunction via an oxidative mechanism.

Remnant-like particles (RLPs) are closely associated with coronary heart disease and can induce endothelial dysfunction through oxidative mechanisms. Many risk factors accelerate the onset of endothelial progenitor cells (EPCs) senescence via increased oxidative stress. In this study, we investigated the effect of RLPs on EPCs senescence and function.

Cyclin-dependent kinase inhibitor p16(INK4a) and telomerase may co-modulate endothelial progenitor cells senescence.

Endothelial cells (ECs) damage is an initial and pivotal step in the formation of atherosclerosis. Endothelial progenitor cells (EPCs), which have been considered as the precursor of ECs, can migrate and home to the site of injured ECs to divide into mature ECs and keep the integrity of the endothelial monolayer. It has been shown that the number and function of EPCs are negatively correlated with various atherosclerotic risk factors.