Estimation of Drug Pharmacokinetics from Breast Feeding: A Simple Method Based on Meta-analysis.

Background: In resource-limited settings, breastfeeding is the healthiest source of nutrition for newborns. For economic/cultural reasons, breastfeeding is the preferred option for the majority of mothers, including HIV-positive mothers.

Objective: The objective of this review is to document parameters characterizing antiretroviral therapy (ARV) diffusion into breast milk associated with the estimated ARV amount ingested by breastfed infant and clinical/biological abnormalities.

Quinine unbound concentration is the best marker for therapeutic drug monitoring.

Quinine monitoring should be based on unbound concentration due to variable unbound fraction in malaria patients.