Publications by authors named "De Jia Huang"

Background: Natural disasters are believed to be associated with cardiovascular disease. This study aimed to explore the changes in mortality due to ischemic heart disease (IHD) and their associations with natural disasters at the global level.

Methods: Country-specific data on the impact of natural disasters, rates of mortality due to IHD and years of life lost (YLL) and socioeconomic variables were obtained for 193 countries for the period from 1990 to 2017.

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  • Macroscopic vascular invasion (MVI) is a severe progression of hepatocellular carcinoma (HCC) that is difficult to treat, and this study compares two treatment methods: transarterial chemoembolization (TACE) combined with radiotherapy (RT) versus RT alone.
  • In a study involving 148 patients with HCC and MVI, those treated with TACE + RT had significantly better overall survival (OS) and progression-free survival (PFS) compared to those who received RT alone, with improvements noted even after adjusting for patient characteristics.
  • The TACE + RT group had comparable rates of complications to the RT group, indicating that combining these treatments may provide better long-term outcomes for patients without increasing adverse effects
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  • - The study compared the effectiveness of stereotactic body radiation therapy (SBRT) and transarterial chemoembolization (TACE) for treating inoperable early-stage hepatocellular carcinoma (HCC) in 326 patients.
  • - Results showed that SBRT had better local control, intrahepatic control, and progression-free survival compared to TACE, while both treatments exhibited similar overall survival rates.
  • - The findings suggest that SBRT is a viable alternative to TACE for patients with inoperable BCLC-A stage HCC, indicating a need for further clinical trials to investigate its benefits more thoroughly.
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Background: Ageing is a risk factor for both coronary artery disease (CAD) and reduced renal function (RRF), and it is also associated with poor prognosis in patients with CAD or RRF. However, little is known about whether the impact of RRF on clinical outcomes are different in CAD patients at different age groups. This study aimed to investigate whether ageing influences the effect of RRF on long-term risk of death in patients with CAD.

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Background: The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients.

Methods: A retrospective analysis was conducted from a single registered database.

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Background: The impact of renal function on the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) remains unclear in coronary artery disease (CAD). This study sought to investigate the value of using NT-proBNP level to predict prognoses of CAD patients with different estimated glomerular filtration rates (eGFRs).

Methods: A retrospective analysis was conducted from a single registered database.

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Background: Elderly patients with coronary artery disease (CAD) frequently complicated with more cardiovascular risk factors, but received fewer evidence-based medications (EBMs). This study explored the association of EBMs compliance in different age groups and the risk of long-term death.

Methods: A retrospective analysis was conducted from a single registered database.

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  • PPFIA1 (liprin-α1) is found to be expressed at higher levels in liver metastatic breast tumors compared to primary tumors, suggesting its role in metastasis.
  • Data from two large databases indicates that high PPFIA1 expression correlates with decreased distant metastasis-free survival in estrogen receptor+ patients, specifically in the estrogen receptor+/N- subgroup.
  • This research suggests that elevated PPFIA1 levels could serve as an independent predictor of increased metastatic relapse risk in estrogen receptor+/N- breast cancer patients, but not in those with estrogen receptor+/N+ or estrogen receptor- statuses.
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  • A study analyzed the use of optimal medical therapy (OMT) in 3,176 coronary artery disease (CAD) patients, finding that only 39.8% were on OMT at discharge, influenced by factors like prior OMT usage and the discharge department.
  • The research showed that OMT significantly reduced all-cause mortality, with a lower risk ratio (HR: 0.65) and more pronounced survival benefits noted in male patients with acute coronary syndrome (ACS).
  • The effectiveness of OMT increased over time, especially after 24 months, and a four-drug combination therapy was more beneficial for ACS patients compared to a three-drug regimen, though this was not the case for stable
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Objective: Obesity is a risk factor for both coronary artery disease (CAD) and chronic renal insufficiency (RI); patients with CAD are prone to obesity and RI. In this study, we try to analyze the effect of body composition on death in CAD patients with mild RI.

Design: Retrospective cohort study.

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Fibrinogen (Fib) is considered to be a potential risk factor for the prognosis of patients with acute coronary syndrome (ACS), but it is unclear whether Fib level have synergistic effects to enhance the prognostic value of the GRACE score in patients with ACS. A retrospective analysis was conducted from a single registered database. 2253 consecutive patients with ACS confirmed by coronary angiography were enrolled and were grouped into 3 categories by the tertiles of admission plasma Fib levels.

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Advanced hepatocellular carcinoma (HCC) with tumor thrombi invading the portal vein and extending into the right atrium (RA) through the hepatic vein is regarded as a terminal-stage condition. Intracardiac tumor thrombus and treatment via liver resection has been reported in the current literature, but results from this therapeutic approach remain unsatisfactory. The present study describes a rare case of HCC with metastatic portal vein, middle hepatic vein, inferior vena cava (IVC) and RA tumor thrombi, and pulmonary metastases.

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Background: There is a controversy surrounding the correlation between fibrinogen (Fib) level and prognosis of coronary artery disease (CAD). We try to investigate the role of the subtypes of CAD in this controversy.

Methods: A retrospective analysis was conducted from a single center CAD registered database.

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Objective: We try to analyse the effect of renal functions on death in CAD patients with different body compositions.

Methods: A retrospective analysis was conducted in 2989 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into two categories: basically preserved renal function (PRF) (eGFR ≥60 ml/min) and obviously reduced renal function (RRF) (eGFR <60 ml/min). The influence of renal insufficiency on mortality of CAD was detected in every tertile of body composition, including body mass index (BMI), body fat (BF) and lean mass index (LMI).

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Fibrinogen (Fib) was considered to be a potential risk factor for the prognosis of patients with coronary artery disease (CAD), but there was lack of the evidence from Chinese contemporary population. 3020 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into 2 categories by the optimal Fib cut-off value (3.17 g/L) for all-cause mortality prediction.

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Background: The Global Registry of Acute Coronary Events (GRACE) risk score has been extensively validated to predict risk during hospitalization in patients with acute coronary syndrome (ACS). Recently, serum calcium has been suggested as an independent predictor for in-hospital mortality in patients with ST-segment elevation myocardial infarction; however, the relationship between the 2 has not been evaluated.

Hypothesis: The combination of GRACE risk score and serum calcium could provide better performance in risk prediction.

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Objectives: Calcium has a critical role in a spectrum of biological processes related to cardiovascular disease. This study aimed to evaluate associations of baseline serum calcium levels with both short-term and long-term outcomes in CAD patients.

Materials And Methods: 3109 consecutive patients with angiography confirmed CAD, admitted to West China hospital of Sichuan University between July 2008 and September 2012 were enrolled and were categorized into quartiles according to admission serum calcium to determine the association of serum calcium level with in-hospital and long-term mortality by multivariable Logistic and Cox regression analysis respectively.

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This study was conducted to investigate the effect of nocturnal light pulses (NLPs) on the feed intake and metabolic rate in geese. Fourteen adult Chinese geese were penned individually, and randomly assigned to either the C (control) or NLP group. The C group was exposed to a 12L:12D photoperiod (12 h light and 12 h darkness per day), whereas the NLP group was exposed to a 12L:12D photoperiod inserted by 15-min lighting at 2-h intervals in the scotophase.

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The purpose of this study was to discuss the present situation of discharge medications in coronary artery disease (CAD) patients with different levels of renal function and assess the potential impact of these medications on the prognosis of this patient population.A retrospective cohort study was conducted. From July 2008 to Jan 2012, consecutive patients with CAD confirmed by coronary angiography of West China Hospital were enrolled and were grouped into 3 estimated glomerular filtration rate (eGFR) categories: ≥60, 30 to 60, and <30 mL/min/1.

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Background: Despite strong evidence linking decreased estimated glomerular filtration rate (eGFR) to worse cardiovascular outcome, the impact of eGFR on mortality in coronary artery disease (CAD) patients with different left ventricular ejection fraction (EF) is not well defined.

Methods: A retrospective cohort study. From Jul.

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Background: Studies focusing on the relationship between calcified lesions and adverse outcomes in the drug-eluting stent (DES) era have presented inconsistent conclusions. The aim of this study was to assess the association between target lesion calcification and adverse outcomes in patients undergoing DES implantation.

Methods: A systematic search was conducted on Medline (Ovid SP, 1946 to 28 February 2014), Embase (Ovid SP, 1974 to 28 February 2014), and the Chinese Biomedical Literature Database (CBM, 1978 to 28 February 2014).

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Serum potassium homeostasis play an important role in myocardial function, but the impact of serum potassium levels on long-term mortality has not been well evaluated. In the current study, we investigated patients with acute coronary syndrome (ACS) and analyzed the relationship between admission serum potassium levels and long-term mortality. Between July 2008 and September 2012, 2369 patients with ACS that was confirmed by coronary angiography were enrolled in this study and completed the follow-up.

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The aim of the present review was to investigate the association between the use of oral β-blockers and prognosis in patients with acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI) treatment. A systematic literature search was conducted in Pubmed (from inception to September 27, 2014) and Embase (Ovid SP, from 1974 to September 29, 2014) to identify studies that compared the outcome of patients with AMI taking oral β-blockers with that of patients not taking after PCI. Systematic review and meta-analysis were performed with random-effects model or fixed-effects model.

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