Construction of thyroid cancer classification and iodine metabolism related diagnostic model using thyroid differentiation score and bioinformation.

To more accurately diagnose and treat patients with different subtypes of thyroid cancer, we constructed a diagnostic model related to the iodine metabolism of THCA subtypes. THCA expression profiles, corresponding clinicopathological information, and single-cell RNA-seq were downloaded from TCGA and GEO databases. Genes related to thyroid differentiation score were obtained by GSVA.

Mixed Ion/Electron Conductive LiN-Mo Interphase Enabling Stable and Ultrahigh-Rate Lithium Metal Anodes.

Lithium (Li) metal is a promising anode for high-energy-density batteries; however, its practical viability is hampered by the unstable metal Li-electrolyte interface and Li dendrite growth. Herein, a mixed ion/electron conductive LiN-Mo protective interphase with high mechanical stability is designed and demonstrated to stabilize the Li-electrolyte interface for a dendrite-free and ultrahigh-current-density metallic Li anode. The LiN-Mo interphase is simultaneously formed and homogeneously distributed on the Li metal surface by the surface reaction between molten Li and MoN nanosheets powder.

Carbon-based composites for rechargeable zinc-air batteries: A mini review.

Rechargeable zinc-air batteries (ZABs) have gained a significant amount of attention as next-generation energy conversion and storage devices owing to their high energy density and environmental friendliness, as well as their safety and low cost. The performance of ZABs is dominated by oxygen electrocatalysis, which includes the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER). Therefore, it is crucial to develop effective bifunctional oxygen electrocatalysts that are both highly active and stable.

Hydrogenolysis of 5-Hydroxymethylfurfural to 2,5-Dimethylfuran Over a Modified CoAl-Hydrotalcite Catalyst.

The catalytic hydrogenolysis of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF) is a promising route towards sustainable liquid fuels with a high energy density. Herein, a novel CuCoNiAl-containing mixed metal oxide catalyst (CuCoNiAl-MMO) was prepared by calcination a layered double hydroxide (LDH) precursor in N at 500 °C, then applied for the catalytic hydrogenolysis of HMF to DMF. The effects of reaction time, reaction temperature and hydrogen pressure on DMF selectivity were investigated.

Mechanical force-induced dispersion of starch nanoparticles and nanoemulsion: Size control, dispersion behaviour, and emulsified stability.

High amylose starch nanoparticles (HS-SNPs) were rapidly synthesised by high-speed circumferential force of homogenisation (3000 and 15,000 rpm) during nanoprecipitation. Morphology and dynamic light scattering analyses showed that HS-SNPs fabricated by stronger circumferential shearing were excellent stabilisers in smaller sizes (20-50 nm). Their aggregates were liable to separate in the aqueous phase with the nano effect under either homogenisation over 6 min or ultrasonication in 2 min.

The mid-domain effect and habitat complexity applied to elevational gradients: Moss species richness in a temperate semihumid monsoon climate mountain of China.

The utility of elevational gradients as tools to test either ecological hypotheses and delineate elevation-associated environmental factors that explain the species diversity patterns is critical for moss species conservation. We examined the elevational patterns of species richness and evaluated the effects of spatial and environmental factors on moss species predicted a priori by alternative hypotheses, including mid-domain effect (MDE), habitat complexity, energy, and environment proposed to explain the variation of diversity. Last, we assessed the contribution of elevation toward explaining the heterogeneity among sampling sites.

First report of fruit blight caused by on sesame in Northeast China.

Sesame ( L.) is an important oilseed crop in China and it is also used in food and health products. In August of 2019, a blight sesame fruit was observed in a field of Liaoyang city, Liaoning province of China.

Molecular fingerprint of precancerous lesions in breast atypical hyperplasia.

Objective: To identify atypical hyperplasia (AH) of the breast by shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS), and to explore the molecular fingerprinting characteristics of breast AH.

Methods: Breast hyperplasia was studied in 11 hospitals across China from January 2015 to December 2016. All patients completed questionnaires on women's health.

On piecewise models and species-area patterns.

Aim: Area thresholds, at which the form of the species-area relationship (SAR) changes abruptly, have played an important role in the theoretical framework of conservation biogeography and biodiversity research. The application of piecewise regressions has been advocated as a rigorous statistical technique to identify such thresholds within SARs, but a large variety of piecewise models remains untested. We explore the prevalence and number of thresholds in SARs and examine whether the currently widely used method for detecting the small island effect (SIE) is robust.

[Characteristics of hydrogen and oxygen isotopes in precipitation and moisture sources in Gaoyou, Jiangsu Province, China].

It is necessary to examine the characteristics of hydrological cycle in Gaoyou area of Jiang-su Province in response to climate change and flood disasters. In this study, 121 atmospheric rain samples were collected and environmental factors were recorded from July 2015 to October 2017. We analyzed the hydrogen and oxygen stable isotopic composition of rain and identify moisture sources in this area.

[Population spatial patterns of grassland plant communities in different slope aspects in the loess hilly area, China.].

We investigated the species composition and diversity of four grassland communities with different slope aspects in the loess hilly area of China. The power law was used to analyze spatial heterogeneity of the community and spatial pattern of the population. The results showed that Artemisia sacrorum was the dominant species and occurred in each site.

[Deuterium isotope characteristics of precipitation infiltrated in the West Ordos Desert of Inner Mongolia, China].

Understanding the soil-profile temporal and spatial distribution of rainwater in arid and semiarid regions provides a scientific basis for the restoration and maintenance of degraded desert ecosystems in the West Ordos Desert of Inner Mongolia, China. In this study, the deuterium isotope (δD) value of rainwater, soil water, and groundwater were examined in the West Ordos Desert. The contribution of precipitation to soil water in each layer of the soil profile was calculated with two-end linear mixed model.

Species-area relationships and additive partitioning of diversity of native and nonnative herpetofauna of the West Indies.

To evaluate the regional biogeographical patterns of West Indian native and nonnative herpetofauna, we derived and updated data on the presence/absence of all herpetofauna in this region from the recently published reviews. We divided the records into 24 taxonomic groups and classified each species as native or nonnative at each locality. For each taxonomic group and in aggregate, we then assessed the following: (1) multiple species-area relationship (SAR) models; (2) - and -values, typically interpreted to represent insularity or dispersal ability; and (3) the average diversity of islands, among-island heterogeneity, γ-diversity, and the contribution of area effect toward explaining among-island heterogeneity using additive diversity partitioning approach.

Detecting the small island effect and nestedness of herpetofauna of the West Indies.

To detect the small island effect (SIE) and nestedness patterns of herpetofauna of the West Indies, we derived and updated data on the presence/absence of herpetofauna in this region from recently published reviews. We applied regression-based analyses, including linear regression and piecewise regressions with two and three segments, to detect the SIE and then used the Akaike's information criterion (AIC) as a criterion to select the best model. We used the NODF (a nestedness metric based on overlap and decreasing fill) to quantify nestedness and employed two null models to determine significance.

DW4TR: A Data Warehouse for Translational Research.

The linkage between the clinical and laboratory research domains is a key issue in translational research. Integration of clinicopathologic data alone is a major task given the number of data elements involved. For a translational research environment, it is critical to make these data usable at the point-of-need.

Imaging features of pediatric pentastomiasis infection: a case report.

We report here a case of pentastomiasis infection in a 3-year-old girl who had high fever, abdominal pain, abdominal tension and anemia. Ultrasound scanning of the abdomen revealed disseminated hyperechoic nodules in the liver and a small amount of ascites. Abdominal MRI showed marked hepatomegaly with disseminated miliary nodules of high signal intensity throughout the hepatic parenchyma on T2-weighted images; retroperitoneal lymphadenopathy and disseminated miliary nodules on the peritoneum were also noted.

Photophysical properties of C60 colloids suspended in water with Triton X-100 surfactant: excited-state properties with femtosecond resolution.

We examine the photophysics of a colloidal suspension of C(60) particles in a micellar solution of Triton X-100 and water, prepared via a new synthesis which allows high-concentration suspensions. The particle sizes are characterized by transmission electron microscopy and dynamic light scattering and found to be somewhat polydisperse in the range of 10-100 nm. The suspension is characterized optically by UV-vis spectroscopy, femtosecond transient absorption spectroscopy, laser flash photolysis, and z-scan.

Bioeliminable nanohydrogels for drug delivery.

One of the most significant obstacles for systematic delivery of nanopayloads is the foreign particle clearance by the mononuclear phagocyte system (MPS). The majority of biocompatible nanopayloads with charged groups on their surface cannot fully evade the clearance by MPS during systemic circulation. For safe and effective targeted nanodrug delivery in vivo, we describe a novel approach for evading the macrophage clearance.

Inhibition on Hepatitis B virus in vitro of recombinant MAP30 from bitter melon.

The gene encoding MAP30 protein was cloned from bitter melon and recombinant MAP30 was expressed and purified. The human hepatoma G2.2.

Nanoparticles for two-photon photodynamic therapy in living cells.

We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.

A modular nanoparticle-based system for reagentless small molecule biosensing.

Metalloprotein tethered CdSe nanoparticles have been generated to provide selective and reagentless maltose biosensing. As opposed to cell or protein detection by semiconducting nanoparticle bioconjugates, a modular method for small-molecule detection using semiconducting nanoparticle bioconjugates has been difficult. Here we report a method for reagentless protein-based semiconducting nanoparticle biosensors.

General, high-affinity approach for the synthesis of fluorophore appended protein nanoparticle assemblies.

Metallothionein fusion proteins allow for site-specific, orthogonal functionalization of proteins to a variety of nanoparticles.

Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.

Tetrahydrobiopterin (BH(4)), not dihydrobiopterin or biopterin, is a critical element required for NO formation by nitric oxide synthase (NOS). To elucidate how BH(4) affects eNOS activity, we have investigated BH(4) redox functions in the endothelial NOS (eNOS). Redox-state changes of BH(4) in eNOS were examined by chemical quench/HPLC analysis during the autoinactivation of eNOS using oxyhemoglobin oxidation assay for NO formation at room temperature.