Neighbor-Guided Pseudo-Label Generation and Refinement for Single-Frame Supervised Temporal Action Localization.

Due to the sparse single-frame annotations, current Single-Frame Temporal Action Localization (SF-TAL) methods generally employ threshold-based pseudo-label generation strategies. However, these approaches suffer from inefficient data utilization, as only parts of unlabeled frames with confidence scores surpassing a predefined threshold are selected for training. Moreover, the variability of single-frame annotations and unreliable model predictions introduce pseudo-label noise.

Humanization of the mouse gene reset telomeres to human length.

Telomeres undergo shortening with each cell division, serving as biomarkers of human aging, which is characterized by short telomeres and restricted telomerase expression in adult tissues. Contrarily, mice, featuring their longer telomeres and widespread telomerase activity, present limitations as models for understanding telomere-related human biology and diseases. To bridge this gap, we engineered a mouse strain with a humanized gene, , wherein specific non-coding sequences were replaced with their human counterparts.

Capsule Networks With Residual Pose Routing.

Capsule networks (CapsNets) have been known difficult to develop a deeper architecture, which is desirable for high performance in the deep learning era, due to the complex capsule routing algorithms. In this article, we present a simple yet effective capsule routing algorithm, which is presented by a residual pose routing. Specifically, the higher-layer capsule pose is achieved by an identity mapping on the adjacently lower-layer capsule pose.

Apical post-infarction ventricular septal defect blockage using the direct externalization and enmeshment to the right ventricular moderator band concept: case series.

Background: Transcatheter treatment in post-infarction ventricular septal defects can be unique and complex; hence, the development of a new technique is needed to improve outcomes.

Summary: We describe two cases in which large and complex apical post-infarction ventricular septal defects were treated with a novel transcatheter approach as salvage and the other due to refusal for open surgical repair. By direct externalization and enmeshment of a device to the right ventricular moderator band, the defect was blocked and immediate improvement of haemodynamics was achieved.

Predicting the risk of iliofemoral vascular complication in complex transfemoral-TAVR using new generation transcatheter devices.

Objective: Design a predictive risk model for minimizing iliofemoral vascular complications (IVC) in a contemporary era of transfemoral-transcatheter aortic valve replacement (TF-TAVR).

Background: IVC remains a common complication of TF-TAVR despite the technological improvement in the new-generation transcatheter systems (NGTS) and enclosed poor outcomes and quality of life. Currently, there is no accepted tool to assess the IVC risk for calcified and tortuous vessels.

Weakly Supervised Temporal Action Localization With Bidirectional Semantic Consistency Constraint.

Weakly supervised temporal action localization (WTAL) aims to classify and localize temporal boundaries of actions for the video, given only video-level category labels in the training datasets. Due to the lack of boundary information during training, existing approaches formulate WTAL as a classification problem, i.e.

New adverse coronary events in valve-in-valve TAVR and native TAVR-A 2-year matched cohort.

Objective: To assess the incidence of new adverse coronary events (NACE) following transcatheter aortic valve replacement (TAVR) and valve-in-valve TAVR (ViV-TAVR).

Background: ViV-TAVR is an accepted treatment for degenerative prostheses among patients with high surgical-risk. TAVR studies have suggested an increased risk of coronary artery obstruction and flow stasis causing thrombus formation.

Structure, magnetism and magnetocaloric effect in a new triangular lattice compound GdCu(OH)Br.

A new triangular lattice compound GdCu(OH)Br has been synthesized by the hydrothermal method. The structure, magnetism and magnetocaloric effect of GdCu(OH)Br have been studied by X-ray diffraction, magnetic susceptibility, isothermal magnetization and specific heat measurements. In GdCu(OH)Br, the Cu ions form a Kagome lattice along the plane, and Gd ions are located in the center of hexagonal holes of the Kagome layer.

Hybrid Dynamic Contrast and Probability Distillation for Unsupervised Person Re-Id.

Unsupervised person re-identification (Re-Id) has attracted increasing attention due to its practical application in the read-world video surveillance system. The traditional unsupervised Re-Id are mostly based on the method alternating between clustering and fine-tuning with the classification or metric learning objectives on the grouped clusters. However, since person Re-Id is an open-set problem, the clustering based methods often leave out lots of outlier instances or group the instances into the wrong clusters, thus they can not make full use of the training samples as a whole.

Efficient double-layer sintering of titanomagnetite concentrate.

The traditional titanomagnetite sintering process consumes high fuel and produces weak-strength sinter. In this study, double-layer sintering was used to solve above problems. The theoretical analysis and sintering pot test results showed that sintering of feed bed constituted by two different-basicity layers could improve mineralization and permeability.

Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene.

Multiple independent sequence variants of the locus have been associated with telomere length and cancer risks in genome-wide association studies. Here, we identified an intronic variable number tandem repeat, VNTR2-1, as an enhancer-like element, which activated hTERT transcription in a cell in a chromatin-dependent manner. VNTR2-1, consisting of 42-bp repeats with an array of enhancer boxes, cooperated with the proximal promoter in the regulation of hTERT transcription by basic helix-loop-helix transcription factors and maintained hTERT expression during embryonic stem-cell differentiation.

Procedural and short-term outcomes of transcatheter closure of ventricular septal defect using lifetech multifunctional occluder: initial experience.

The Lifetech Multifunctional occluder is a versatile device with an improved delivery and flexibility that reduces the risk of atrioventricular block. This is a retrospective, descriptive, pilot study done in 25 patients who underwent transcatheter closure of ventricular septal defect using Lifetech Multifunctional occluder from February 2017 to January 2018.The average age was 9.

Crispr/Cas9-mediated cleavages facilitate homologous recombination during genetic engineering of a large chromosomal region.

Homologous recombination over large genomic regions is difficult to achieve due to low efficiencies. Here, we report the successful engineering of a humanized mTert allele, hmTert, in the mouse genome by replacing an 18.1-kb genomic region around the mTert gene with a recombinant fragment of over 45.

Author Correction: Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells.

Telomerase is expressed in adult mouse, but not in most human, tissues and mouse telomeres are much longer than those in humans. This interspecies difference of telomere homeostasis poses a challenge in modeling human diseases using laboratory mice. Using chromatinized bacterial artificial chromosome reporters, we discovered that the 5' intergenic region, introns 2 and 6 of human telomerase gene (hTERT) were critical for regulating its promoter in somatic cells.

Fusion of Multiple Person Re-id Methods With Model and Data-Aware Abilities.

Person re-identification (person re-id) has attracted rapidly increasing attention in computer vision and pattern recognition research community in recent years. With the goal of providing match ranking results between each query person image and the gallery ones, the person re-id technique has been widely explored and a large number of person re-id methods have been developed. As these algorithms leverage different kinds of prior assumptions, image features, distance matching functions, et al.

Fine-Grained Image Classification Using Modified DCNNs Trained by Cascaded Softmax and Generalized Large-Margin Losses.

We develop a fine-grained image classifier using a general deep convolutional neural network (DCNN). We improve the fine-grained image classification accuracy of a DCNN model from the following two aspects. First, to better model the h -level hierarchical label structure of the fine-grained image classes contained in the given training data set, we introduce h fully connected (fc) layers to replace the top fc layer of a given DCNN model and train them with the cascaded softmax loss.

Regulation of human and mouse telomerase genes by genomic contexts and transcription factors during embryonic stem cell differentiation.

Differential regulation of telomerase reverse transcriptase (TERT) genes contribute to distinct aging and tumorigenic processes in humans and mice. To study TERT regulation, we generated mouse embryonic stem cell (ESC) lines containing single-copy bacterial artificial chromosome (BAC) reporters, covering hTERT and mTERT genes and their neighboring loci, via recombinase-mediated BAC targeting. ESC lines with chimeric BACs, in which two TERT promoters were swapped, were also generated.

Muscle gap approach under a minimally invasive channel technique for treating long segmental lumbar spinal stenosis: A retrospective study.

This study aimed to compare the efficacy of muscle gap approach under a minimally invasive channel surgical technique with the traditional median approach.In the Orthopedics Department of Traditional Chinese and Western Medicine Hospital, Tongzhou District, Beijing, 68 cases of lumbar spinal canal stenosis underwent surgery using the muscle gap approach under a minimally invasive channel technique and a median approach between September 2013 and February 2016. Both approaches adopted lumbar spinal canal decompression, intervertebral disk removal, cage implantation, and pedicle screw fixation.

A Weight-Adaptive Laplacian Embedding for Graph-Based Clustering.

Graph-based clustering methods perform clustering on a fixed input data graph. Thus such clustering results are sensitive to the particular graph construction. If this initial construction is of low quality, the resulting clustering may also be of low quality.

[Effect of comprehensive schistosomiasis control measures in Kaihua County from 1996 to 2015].

Objective: To evaluate the control effect of comprehensive measures of schistosomiasis after its transmission interruption in Kaihua County, Zhejiang Province, so as to provide the references for further consolidation of schistosomiasis control.

Methods: The data of snail survey and control, as well as environmental reform in Kaihua County were collected and analyzed from 1996 to 2015.

Results: From 1996 to 2015, totally 2 635 snail habitats and 102.

Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes.

The human telomerase reverse transcriptase () gene is repressed in most somatic cells, whereas the expression of the mouse gene is widely detected. To understand the mechanisms of this human-specific repression, we constructed bacterial artificial chromosome (BAC) reporters using human and mouse genomic DNAs encompassing the genes and neighboring loci. Upon chromosomal integration, the hTERT, but not the mTert, reporter was stringently repressed in telomerase-negative human cells in a histone deacetylase (HDAC)-dependent manner, replicating the expression of their respective endogenous genes.

Human Specific Regulation of the Telomerase Reverse Transcriptase Gene.

Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue homeostasis by maintaining telomere length. Although there is a high conservation between human and mouse TERT genes, the regulation of their transcription is significantly different in these two species. Whereas mTERT expression is widely detected in adult mice, hTERT is expressed at extremely low levels in most adult human tissues and cells.

Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment.

The transcription of human telomerase gene hTERT is regulated by transcription factors (TFs), including Sp1 family proteins, and its chromatin environment. To understand its regulation in a relevant chromatin context, we employed bacterial artificial chromosome reporters containing 160 kb of human genomic sequence containing the hTERT gene. Upon chromosomal integration, the bacterial artificial chromosomes recapitulated endogenous hTERT expression, contrary to transient reporters.