Fe-Catalyzed Fluorosulfonylation of Alkenes via Sulfur Dioxide Insertion: Synthesis of Lactam-Functionalized Alkyl Sulfonyl Fluorides.

A novel Fe-catalyzed fluorosulfonylation of alkenes with NaSO and -fluorobenzenesulfonimide (NFSI) for assembling various lactam-functionalized alkyl sulfonyl fluorides is disclosed. In this reaction, NaSO acts as both an SO source and a reductant. Furthermore, the resulting products can be efficiently transformed into valuable chemicals, including sulfonyl esters and sulfonamides, via the sulfur(VI) fluoride exchange (SuFEx) click reaction.

ZIF-67-modified magnetic nanoparticles for extraction of phenoxy carboxylic acid herbicides.

Phenoxy carboxylic acid (PCA) herbicides are commonly used herbicides that can easily accumulate in soil, groundwater, crops, and vegetable surfaces. Thus, they pose a serious risk to human health. Accurate detection of trace amounts of PCAs in various matrixes is crucial.

On the Security of a PUF-Based Authentication and Key Exchange Protocol for IoT Devices.

Recently, Roy et al. proposed a physically unclonable function (PUF)-based authentication and key exchange protocol for Internet of Things (IoT) devices. The PUF protocol is efficient, because it integrates both the Node-to-Node (N2N) authentication and the Node-to-Server (N2S) authentication into a standalone protocol.

Study on the flocculation mechanism of a bioflocculant from Acinetobacter sp. TH40 combined with graphene oxide for the removal of metal ions from water.

In order to realize the simultaneous removal of nine metal ions from water, in this study, an excellent flocculant suitable for the simultaneous removal of multiple metal ions in water was developed by using the excellent flocculation properties of graphene oxide (GO) combined with biological flocculants. First, this study investigated the concentrations and pollution levels of nine metal pollutants in surface water and groundwater of a typical city in central China. The maximum concentrations of these nine metal ions were Al 0.

Xiaotan Sanjie decoction normalizes tumor permissive microenvironment in gastric cancer (Review).

Gastric cancer (GC) develops in a complex tissue environment, the tumor microenvironment (TME), which it relies on for persistent proliferation, migration, invasion and metastasis. Non‑malignant stromal cell types within the TME are regarded as a clinical meaningful target with the lower risk of resistance and tumor relapse. Studies have revealed that the Xiaotan Sanjie decoction, which is formulated on the basis of the theory of phlegm syndrome, a Traditional Chinese Medicine concept, modulates released factors such as transforming growth factor‑β from tumor cells, immune cells, cancer‑associated fibroblasts, extracellular matrix, as well as vascular endothelial growth factor involved in the process of angiogenesis within the TME.

Phase Change Material Enhanced Radiative Cooler for Temperature-Adaptive Thermal Regulation.

Passive radiative cooling (PRC), as an electricity-free and environmentally friendly cooling strategy, is highly desirable in improving the global energy landscape. Despite numerous efforts, most designs for PRC are so devoted to improving the cooling performance in the daytime that they neglect the triggered overcooling at night. Herein, we approached an effective design for temperature-adaptive thermal management through integrating PRC and temperature control of room-temperature phase change material.

Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling.

To determine the effect and mechanism of the long non-coding RNA (lncRNA) ncRuPAR (non-protein coding RNA, upstream of coagulation factor II thrombin receptor [F2R]/protease-activated receptor-1 [PAR-1]) in human gastric cancer. HGC-27-ncRuPAR overexpression and MGC-803-ncRuPAR-RNAi knockdown gastric cancer cell lines were established. We assessed the effect of ncRuPAR on cell proliferation, apoptosis, migration, and invasion using Cell Counting Kit 8, flow cytometry, scratch and transwell assays, respectively.

Research progress in targeted therapies for gastric cancer.

Patients with advanced gastric cancer experience rapid disease progression with limited survival, high mortality, and a lack of surgical options. Thus, radiochemotherapy or a combination of chemotherapeutics with targeted therapy is the mainstay of treatment. In comparison to the treatment of other malignant tumors, in gastric cancer, the development of molecularly targeted drugs has been relatively slow.

Xiaotansanjiefang inhibits the viability of colorectal cancer cells via Jagged 1/Notch 3/Snail signaling pathway.

The purpose of this study is to explore the anti-colorectal cancer of Xiaotansanjiefang, a famous traditional Chinese medicine, and its potential anti-cancer mechanism. In this study, the HCT116 cell spheres were prepared as in vitro study model. We found the Xiaotansanjiefang medication was able to inhibit the proliferation of HCT116 cell spheres in a dose-dependent manner, especially in 3 and 6 mg/ml Xiaotansanjiefang medication treated groups.

Adhesive hydrogel wrap loaded with Netrin-1-modified adipose-derived stem cells: An effective approach against periarterial inflammation after endovascular intervention.

Endovascular interventions, such as balloon dilation and stent implantation, are currently recommended as the primary treatment for patients with peripheral artery disease (PAD), greatly improving patient prognosis. However, the consequent lumen restenosis that occurs after endovascular interventions has become an important clinical problem. Inflammation has been proven to be crucial to postoperative restenosis.

Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape.

Diabetic patients suffer from peripheral nerve injury with slow and incomplete regeneration owing to hyperglycemia and microvascular complications. This study develops a graphene-based nerve guidance conduit by incorporating natural double network hydrogel and a neurotrophic concentration gradient with non-invasive treatment for diabetics. GelMA/silk fibroin double network hydrogel plays quadruple roles for rapid setting/curing, suitable mechanical supporting, good biocompatibility, and sustainable growth factor delivery.

Poly(lactic acid)/artificially cultured diatom frustules nanofibrous membranes with fast and controllable degradation rates for air filtration.

Unlabelled: The worldwide pandemic, coronavirus COVID-19, has been posing a serious threat to the global economy and security in last 2 years. The monthly consumption and subsequent discarding of 129 billion masks (equivalent to 645,000 tons) pose a serious detrimental impact on environmental sustainability. In this study, we report a novel type of nanofibrous membranes (NFMs) with supreme filtration performance and controllable degradation rates, which are mainly composed of polylactic acid (PLA) and artificially cultured diatom frustules (DFs).

Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression.

Objectives: Ziyin Huatan Recipe (ZYHT), a traditional Chinese medicine comprised of Lilii Bulbus, Pinelliae Rhizoma, and Hedyotis Diffusa, has shown promise in treating gastric cancer (GC). However, its potential mechanism has not yet been clearly addressed. This study aimed to predict targets and molecular mechanisms of ZYHT in treating GC by network pharmacology analysis and to explore the role of ZYHT in GC both in vitro and in vivo.

A novel fluorescent probe with aggregation induced emission (AIE) effect based on 1,4-dihydropyridine and its applications.

A fluorescent hydrazine hydrate probe (DMA) based on 1,4-dihydropyridine derivatives was designed and synthesized. The fluorescence emission peak of this probe is in the near-infrared region (667 nm), which has good selectivity to hydrazine hydrate and low detection limit (11 nM). Importantly, the probe exhibits aggregation-induced emission (AIE) characteristics.

Fast Self-Healing Superhydrophobic Thermal Energy Storage Coatings Fabricated by Bio-Based Beeswax and Artificially Cultivated Diatom Frustules.

Diatom frustules (DFs) with delicate hierarchical pores and a large specific surface area are extracted from artificially cultured diatoms, showing their utilization potential as shape-stabilized phase change materials (ss-PCMs). Herein, we successfully prepared a fully biomass-based ss-PCM, superhydrophobic thermal energy storage (STES) coating by employing beeswax (BW) as phase change materials (PCMs) and DFs as supporting materials via a facile spraying method. DFs can adsorb as much as 65 wt % BW without leakage, accompanied with a high heat storage capacity of 112.

Facile Fabrication of Novel Multifunctional Lubricant-Infused Surfaces with Exceptional Tribological and Anticorrosive Properties.

The large-area preparation of excellent lubricating materials with good resistance to leakage and an oxidation atmosphere and ease of replenishment has remained a challenge. Here, inspired by the pitcher slippery surface, we have fabricated multifunctional lubricant-infused surfaces (LISs) via a scalable technique, in which the solid lubricants and the lubricant oil are reciprocally well-combined to overcome their respective weakness. The designed LIS coating exhibits a multiple lubrication ability with a coefficient of friction of 0.

Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity.

Background And Objective: Neurotoxicity is a common side effect of oxaliplatin; the effect of current drugs such as methylcobalamin and gabapentine is not obvious. Astragaloside IV (AS-IV) is an important active ingredient of , which can protect the nervous system and inhibit tumor growth to a certain extent. However, whether AS-IV can reduce oxaliplatin neurotoxicity and its molecular mechanism remain unclear.

Aligned Graphene Mesh-Supported Double Network Natural Hydrogel Conduit Loaded with Netrin-1 for Peripheral Nerve Regeneration.

The gold standard treatment for peripheral nerve injuries (PNIs) is the autologous graft, while it is associated with the shortage of donors and results in major complications. In the present study, we engineer a graphene mesh-supported double-network (DN) hydrogel scaffold, loaded with netrin-1. Natural alginate and gelatin-methacryloyl entangled hydrogel that is synthesized via fast exchange of ions and ultraviolet irradiation provide proper mechanical strength and excellent biocompatibility and can also serve as a reservoir for netrin-1.

LncRNA CCAT2 promotes proliferation and suppresses apoptosis of colorectal cancer cells.

Purpose: To investigate the effects of long non-coding ribonucleic acid (lncRNA) colorectal cancer (CRC)-associated transcript 2 (CCAT2) expression on proliferation and apoptosis of colorectal cancer (CRC) cells.

Methods: Data of lncRNA expression in CRC were downloaded from the cancer genome atlas (TCGA) database for differential expression and survival analyses, and real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was employed to analyze the expression level of lncRNA CCAT2 in 80 cases of CRC and adjacent tissues collected as well as normal colorectal cells and CRC cell lines selected. The cells successfully transfected were collected for the detection of the effects on apoptosis and proliferation.

Xiaotan Jieyu Prescription Alleviates Breast Precancerous Lesions through PI3K/Akt Signaling Pathway.

Methods: The successfully established breast precancerous lesion rat model and normal healthy rats were randomly assigned into the blank (BLA), model (MOD), XTJY-low (LD), XTJY-medium (MD), XTJY-high (HD), and tamoxifen (TAM) groups. Different concentrations of XTJY and saline were supplied by intragastric administration for 4 consecutive weeks to assess the protective effect of XTJY on the progress of the breast precancerous lesion in rats involving the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway.

Results: In this study, it determined that 10 mg/each rat DMBA-combined estrogen and progesterone induction for 10 weeks was the optimal condition for the establishment of the breast precancerous lesion rat model.

ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3K/AKT Pathway.

In recent years, traditional Chinese medicine has played an important role in the treatment of gastric cancer in China. ZiYinHuaTan (ZYHT) recipe was developed for advanced gastric cancer and had shown its promising value in the clinic. In this study, we explore the effect of ZYHT on gastric cancer in vitro and in vivo.

Analysis of Low-Velocity Impact Resistance of Carbon Fiber Reinforced Polymer Composites Based on the Content of Incorporated Graphite Fluoride.

As a graphite derivative, graphite fluoride (GrF) has a remarkable fracture toughness improvement effect on epoxy materials. The fracture toughness variation of the epoxy could exert an influence on the low velocity impact resistance of the corresponding carbon fiber reinforced polymer (CFRP) composite. Therefore, the dependence of the low velocity impact resistance of the incorporated CFRP on the GrF content is worth analyzing.

Curcumin Alleviates Oxaliplatin-Induced Peripheral Neuropathic Pain through Inhibiting Oxidative Stress-Mediated Activation of NF-κB and Mitigating Inflammation.

Oxaliplatin is a first-line clinical drug in cancer treatment and its side effects of peripheral neuropathic pain have also attracted much attention. Neuroinflammation induced by oxidative stress-mediated activation of nuclear factor-kappa B (NF-κB) plays an important role in the course. Current studies have shown that curcumin has various biological activities like antioxidant, anti-inflammatory, antitumor and so on, while few studies were conducted about its role in oxaliplatin-induced peripheral neuropathic pain.