Publications by authors named "Dayna Ellis"
Occidiofungin's chemical stability and in vitro potency against Candida species.
Antimicrob Agents Chemother
February 2012
Occidiofungin is a cyclic glyco-lipopeptide produced by Burkholderia contaminans. MICs against Candida species were between 0.5 and 2.
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- * A small volume fermentation method was developed, allowing rapid testing of different factors affecting mutacin 1140 production, identifying lactose as the best carbon source.
- * Adding high concentrations of CaCl(2) and MgSO(4) boosted production, while ZnCl(2) and FeCl(3) hindered it, ultimately leading to over a 100-fold increase in yield, estimated at ~10 mg/L.
Bacterial strain Burkholderia contaminans MS14 was isolated from soil that suppressed brown patch disease of lawn grass. An antifungal compound was purified from the liquid culture of this bacterium. In this study, complete covalent structures of two purified closely related antifungal compounds were determined by the experiments of TOCSY, NOESY, ROESY, 13C HSQC 2D NMR, and ESI-MS and GC.
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