Intramuscular injection of Bothrops jararaca venom provoked acute kidney injury (AKI): Underpinned by impaired renal filtration, Na handling, and tissue damage.

Globally, about 2.5 million people are victims of snakebites annually. In Brazil, the most clinically relevant snake is the Bothrops jararaca.

The Triad Na Activated Na Channel (Nax)-Salt Inducible KINASE (SIK) and (Na + K)-ATPase: Targeting the Villains to Treat Salt Resistant and Sensitive Hypertension.

The Na-activated Na channel (Nax) and salt-inducible kinase (SIK) are stimulated by increases in local Na concentration, affecting (Na + K)-ATPase activity. To test the hypothesis that the triad Nax/SIK/(Na + K)-ATPase contributes to kidney injury and salt-sensitive hypertension (HTN), uninephrectomized male Wistar rats (200 g; = 20) were randomly divided into 4 groups based on a salt diet (normal salt diet; NSD-0.5% NaCl-or high-salt diet; HSD-4% NaCl) and subcutaneous administration of saline (0.

Luminal ANG II is internalized as a complex with ATR/ATR heterodimers to target endoplasmic reticulum in LLC-PK cells.

ANG II has many biological effects in renal physiology, particularly in Ca handling in the regulation of fluid and solute reabsorption. It involves the systemic endocrine renin-angiotensin system (RAS), but tissue and intracrine ANG II are also known. We have shown that ANG II induces heterodimerization of its AT and AT receptors (ATR and ATR) to stimulate sarco(endo)plasmic reticulum Ca-ATPase (SERCA) activity.