Does Adopting Western Low-density Lipoprotein Cholesterol Targets Expose Indians to a Higher Risk of Cardiovascular Events? Expert Opinion From the Lipid Association of India.

Adverse cardiovascular (CV) events have declined in Western countries due at least in part to aggressive risk factor control, including dyslipidemia management. The American and European (Western) dyslipidemia treatment guidelines have contributed significantly to the reduction in atherosclerotic cardiovascular disease (ASCVD) incidence in the respective populations. However, their direct extrapolation to Indian patients does not seem appropriate for the reasons described below.

BEAT Survey: A Cross-sectional Study of Resting Heart Rate in Young (18-55 Year) Hypertensive Patients.

Background: Studies in Caucasian population have shown that sustained elevation of heart rate (HR) is associated with increased cardiovascular mortality and morbidity in patients with heart failure (HF), myocardial infarction (MI). However, resting HR is not so well-studied in Indian hypertensive patients.

Materials And Methods: BEAT is a cross-sectional survey to evaluate the resting HR in young (18-55 years) patients in India.

Correlation between peripheral arterial disease and coronary artery disease using ankle brachial index-a study in Indian population.

Objective: To study the prevalence of peripheral arterial disease (PAD) of the lower limbs in a high-risk population and its correlation with coronary artery disease (CAD), using the ankle brachial index (ABI).

Methods: The present study was conducted in randomly selected indoor patients >45 years of age with one or more risk factors for PAD admitted in the cardiology and medicine wards in a tertiary care institute.

Results: Based on ABI <0.

Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.

Aim: Acute coronary syndrome (ACS) is an inflammatory disease. Cytokines are the central regulators of inflammation and may be a cause or marker of atherosclerosis. Accumulating evidence suggests that polymorphisms at promoter regions of various cytokine genes are known to be associated with their expression levels.

Efficacy and tolerability of trandolapril in mild to moderate hypertension--a double blind comparative clinical trial with enalapril in Indian population.

Several large scale clinical trials have demonstrated that angiotensin converting enzyme inhibitors offer cardiovascular and renal protection independent of their effects on systolic BP. Trandolapril is a new angiotensin converting enzyme inhibitor approved for the treatment of hypertension. The potential advantages of this drug are long duration of action and better tolerability.