The depsidones from marine sponge-derived fungus IB151 as an anti-MRSA agent: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies.

Methicillin-resistant (MRSA) is an emerging nosocomial pathogen among hospitalized patients, with high morbidity and mortality rates. The discovery of a novel antibacterial is urgently needed to address this resistance problem. The present study aims to explore the antibacterial potential of three depsidone compounds: 2-clorounguinol (), unguinol (), and nidulin (), isolated from the marine sponge-derived fungus IB1, both and .

Traditional Uses, Phytochemistry and Biological Activities of Species: A Systematic Review.

The genus (Schott) G. Don consists of 113 species distributed across Asia, Southeast Asia, and Australia. plants grow in tropical and subtropical forests with humid lowlands.

Genus : A Review of Its Distribution, Traditional Uses, Phytochemistry, Biological Activities and Propagation.

Almost 50 species of plants were reviewed in this work and the main objective is to critically analyse their distribution, phytochemical content, biological activity, and propagation. Moreover, the information would be useful in promoting the relevant uses of the plant, especially in the medicinal fields based on in vitro and in vivo studies. To this end, scientific sources, including theses, PubMed, Google Scholar, International Islamic University Malaysia IIUM EBSCO, PubChem, and Elsevier, were accessed for publications regarding the genus in this review.

Inventory, constituents and conservation of biologically important Sumatran plants.

An inventory of Sumatran medicinal plants, and reports on their chemistry and conservation carried out in the last three decades are reviewed.

The coloring constituents of Scleroderma sinnamariense (Sclerodermaceae).

Two known coloring constituents, methyl 4,4'-dimethoxyvulpinate (1) and 4,4'-dimethoxyvulpinic acid (2) have been isolated from the fruit body of fungus Scleroderma sinnamariense Mont. The methanolic extract, its fractions and compound (2) showed moderate activity to inhibit the growth of some pathogenic testing microbes used.

The quaternary indole alkaloids from two Sumatran Lerchea species.

The Sumatran forest plants Lerchea cf. bracteata and L. parviflora were found to contain alkaloids and their extract showed siginificant activity toward some testing pathogenic microbes.

Chemical constituents from tiger's betel, Piper porphyrophyllum N.E.Br. (Fam. Piperaceae).

Seven flavonoid compounds have been isolated from the aerial parts of tiger's betel (Piper porphyrophyllum), which were identified as 5,7-dimethoxyflavone, 4',5,7-trimethoxy-flavone, 3',4',5,7-tetramethoxyflavone, 4'-hydroxy-3',5,7-trimethoxyflavone, 5-hydroxy-3',4',7-trimethoxyflavone, 4',5-dihydroxy-3',7-dimethoxyflavone and 5-hydroxy-7-methoxyflavanone. The identification of all compounds was achieved by physical properties and spectroscopically. These data were also confirmed by comparison with previously reported spectral data.

A polyisoprenylated ketone from Calophyllum enervosum.

A polyisoprenylated ketone named enervosanone has been isolated from the stem bark of Calophyllum enervosum together with three known compounds, cambogin, osajaxanthone and epicatechin. Their structures were determined by spectroscopic analysis. The antimicrobial evaluations of the isolated compounds were also reported.