Gene Polymorphism Influences Methamphetamine-Induced Psychosis.

is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population.