Publications by authors named "Dayana M Gueth"
Article Synopsis
- The effectiveness of bioactive drugs in cancer treatment is limited by their ability to cross cell membranes, which often leads to therapy resistance due to insufficient drug accumulation inside cells.
- Researchers discovered a mechanism that enhances the movement of the well-known anti-cancer drug doxorubicin across cell membranes, using lipid analogues to create a temporary channel that aids drug translocation.
- Their findings, supported by molecular simulations and tests on genetically modified mice with breast cancer, highlight how membrane structure restricts drug efficacy and offer a potential solution for improving the effectiveness of existing cancer treatments.
