Publications by authors named "Dawn Storey"
Article Synopsis
- Neutropenic sepsis is a frequent issue for cancer patients undergoing treatment, leading to different practices regarding when to switch from intravenous (IV) to oral antibiotics.
- The study aimed to assess the clinical and cost-effectiveness of switching to oral antibiotics early for low-risk patients compared to standard IV care.
- The trial included 129 participants from 19 UK oncology centers but was closed early due to not meeting recruitment goals, preventing a definitive conclusion about the effectiveness of the early switch.
Article Synopsis
- The study aimed to see if switching to oral antibiotics early in adults with neutropenic sepsis was just as effective as switching later.
- It involved 129 participants who were randomly assigned to start oral antibiotics within 12-24 hours or continue intravenous treatment for at least 48 hours.
- Although the early switch showed some benefits like a shorter hospital stay, it was not proven to be non-inferior overall when considering all patients in the treatment groups.
Background: Radiotherapy and chemotherapy are used to improve survival in colorectal cancer but adverse effects can be a problem. Severe adverse effects may result in dose reduction or cessation of treatment, which have an impact on survival. Coriolus versicolor (Trametes versicolor or 'Turkey Tail') mushroom and its extracts have been used by cancer patients to help with adverse effects.
View Article and Find Full Text PDFIntroduction: People living with and beyond cancer are vulnerable to a number of physical, functional and psychological issues. Undertaking a holistic needs assessment (HNA) is one way to support a structured discussion of patients' needs within a clinical consultation. However, there is little evidence on how HNA impacts on the dynamics of the clinical consultation.
View Article and Find Full Text PDFChemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a variety of chemotherapeutic agents. Clinicians are cognizant of the negative impact of CIPN on cancer treatment outcomes and patients' psychosocial functioning and quality of life. In an attempt to alleviate this problem, clinicians and patients try various therapeutic interventions, despite limited evidence to support efficacy of these treatments.
View Article and Find Full Text PDFChemotherapy-induced peripheral neuropathy (CIPN) lacks standardized clinical measurement. The objective of the current secondary analysis was to examine data from the CIPN Outcomes Standardization (CI-PeriNomS) study for associations between clinical examinations and neurophysiological abnormalities. Logistic regression estimated the strength of associations of vibration, pin, and monofilament examinations with lower limb sensory and motor amplitudes.
View Article and Find Full Text PDFBackground: Although it is increasingly recognized that cancer patients often have sleep problems, we lack data on their prevalence and associations in representative clinical populations. We aimed to determine (i) the prevalence of sleep problems amongst outpatients of a cancer centre and (ii) the association with medical variables, emotional distress and pain.
Methods: Secondary analysis of self-report and medical data on 2862 cancer centre outpatients.
Context: We know little about how many outpatients of a modern cancer center suffer from clinically significant unrelieved pain and the characteristics of these patients to guide better care.
Objectives: To determine the prevalence of clinically significant pain (CSP) in the outpatients of a regional cancer center and the association with distress and other variables.
Methods: A secondary analysis of cross-sectional, self-reported and clinical data from 2768 patients reattending selected clinics of a regional National Health Service cancer center in the U.
Traditionally, medical oncology has focused on the active period of diagnosis, treatment and follow-up of cancer patients, and palliative medicine, the pre-terminal and end-of-life phases. Palliative medicine physicians have particular expertise in communication and symptom control, especially, for example, with pain management. Medical oncologists also have need of excellent communication skills and knowledge of supportive care issues, such as the management of emesis, bone marrow suppression, mucositis, neuropathy, and symptoms created by treatment.
View Article and Find Full Text PDFBackground: Clinicopathological features and outcome of women with endometrioid and serous ovarian adenocarcinoma were compared.
Methods: Between 1984 and 2004, baseline and follow-up data were prospectively recorded on 1545 patients with ovarian cancer. Of these, 270 had pure endometrioid tumors; 659 had pure serous adenocarcinoma of the ovary.