Exploring fingerprints for antidiabetic therapeutics related to peroxisome proliferator-activated receptor gamma (PPARγ) modulators: A chemometric modeling approach.

This study demonstrated the correlation of molecular structures of Peroxisome proliferator-activated receptor gamma (PPARγ) modulators and their biological activities. Bayesian classification, and recursive partitioning (RP) studies have been applied to a dataset of 323 PPARγ modulators with diverse scaffolds. The results provide a deep insight into the important sub-structural features modulating PPARγ.

A review on biological biohydrogen production: Outlook on genetic strain enhancements, reactor model and techno-economics analysis.

Modernisation of industrial and transportation sector would have not imaginable without the help of fossil fuels, but constant usage has led to many environmental concerns. As a step forward, for safer next generation living we are forced to look into green fuels like bio‑hydrogen and higher alcohols. This review mainly focuses on bio‑hydrogen production via biological pathways, genetic improvements, knowledge gap, economics, and future directions.

IV-GNN : interval valued data handling using graph neural network.

Interval-valued data is an effective way to represent complex information where uncertainty, inaccuracy etc. are involved in the data space and they are worthy of taking into account. Interval analysis together with neural network has proven to work well on Euclidean data.

Removal of toxic metals from wastewater environment by graphene-based composites: A review on isotherm and kinetic models, recent trends, challenges and future directions.

Access to clean water has reduced in recent years due to pollution and man-made activities. Wastewater treatment regimens are many such as electrocoagulation, adsorption, ozonation, membrane and advanced oxidation processes. Owing to economical, resource availability and ease of operation adsorption has upper hand over all other methods employed in wastewater treatment.

Four stroke diesel engine performance and emission studies of ethanol recovered from Kappaphycus alvarezii reject -solid food waste mixed substrates and its blends.

Bioethanol is an eco-friendly green fuel, owing to its production from sustainable bio-based sources. In this study, bioethanol (BE) is produced from Kappaphycus alverezii reject (KR) blended with Solid Food Waste (SFW). This bioethanol is blended with petroleum-based diesel (PBD) in the following proportions: 15%, 20% and 25% for further studies.

Synthesis of zinc chloride activated eco-friendly nano-adsorbent (activated carbon) from food waste for removal of pollutant from biodiesel wash water.

Food waste has been a complex component added to municipal solid waste, making it a major reason for the evolution of greenhouse gases, foul odour and a dwelling habitat for insects and microbes. Diversion of the mixed food waste (unsegregated) to useful materials (activated carbon) would have immense industrial significance. In this study, rice, vegetables, oil and spice (WCVR); mixed fruit peels including banana peel, pomegranate peel, orange peel and lemon peel (MFPW); plain rice (WCR) and mixed food waste (rice, dhal, vegetables, fruits, meat and bones) (MFW) were used.

Fused CNN-LSTM deep learning emotion recognition model using electroencephalography signals.

The traditional machine learning-based emotion recognition models have shown effective performance for classifying Electroencephalography (EEG) based emotions. The different machine learning algorithms outperform the various EEG based emotion models for valence and arousal. But the downside is to devote numerous efforts to designing features from the given noisy signals which are also a very time-consuming process.

Effect of COVID-19 pandemic on air quality: a study based on Air Quality Index.

The COVID-19 pandemic has significantly affected economic activities all around the world. Though it took a huge amount of human breathes as well as increases unemployment, it puts a positive impression on the environment. To stop the speedy extend of this disease, the maximum Government has imposed a strict lockdown on their citizens which creates a constructive impact on the atmosphere.

Superabsorbent Wound Dressing for Management of Patients With Moderate-to-Highly Exuding Chronic Leg Ulcers: An Early Stage Model-Based Benefit-Harm Assessment.

The aim of the research is to assess the benefit-harm of superabsorbent polymers wound dressings based on polyacrylate polymers (SAPs) compared with standard of care (SoC) dressing mix for patients with moderate-to-highly exuding hard-to-heal leg ulcers. The SoC dressings mix was composed of other superabsorbents in 29% of cases, antimicrobials 26%, foams 20%, alginates 5%, and other dressings 19% weighted according to their frequency. We have used the decision-analytic modeling method, Markov process, as an adequate analytical solution for medical prognosis.

Recovery and recycle of wastewater contaminated with heavy metals using adsorbents incorporated from waste resources and nanomaterials-A review.

Recovery and recycle of wastewater are essential because of the need of huge quantities of water everywhere in this world. Presence of heavy metals in wastewater such as iron (Fe), molybdenum (Mo), manganese (Mn), zinc (Zn), nickel (Ni), copper (Cu), vanadium (V), cobalt (Co), tungsten (W), chromium (Cr), arsenic (As), silver (Ag), antimony (Sb), cadmium (Cd), mercury (Hg), lead (Pd), uranium (U), etc is the serious environmental issues and risk for human and animal health. Adsorbents are simple and low-cost methods to treat the pollutants and heavy metals of wastewater.

Electro-kinetically driven route for highly sensitive blood pathology on a paper-based device.

Enhancing the sensitivity of colorimetric detection in paper-devices is a quintessential step in achieving frugal diagnosis. Here, we demonstrate an effective way of improving the detection sensitivity of paper-based devices, as mediated by electro-kinetic mechanisms. By directly employing blood plasma, we investigate the electro-kinetic clustering of glucose, a neutral molecule in paper devices.

Use of sensors to quantify procedural idle time: Validity evidence for a new mastery metric.

Background: Quantification of mastery is the first step in using objective metrics for teaching. We hypothesized that during orotracheal intubation, top tier performers have less idle time compared to lower tier performers.

Methods: At the Anesthesiology 2018 Annual Meeting, 82 participants intubated a normal airway simulator and a burnt airway simulator.

Learning-based classification of valence emotion from electroencephalography.

The neuroimaging research field has been revolutionized with the development of human cognitive functions without the use of brain pathways. To assist such systems, electroencephalography (EEG) based measures play an important role. In this study, the publicly available database of emotion analysis using physiological signals, has been used to identify the human emotions such as valence (positive/negative) from the given recorded EEG signals.

ESTIMATION OF NEUTRON SCATTER CORRECTION FOR CALIBRATION OF PERSONNEL DOSIMETER AND DOSERATEMETER AGAINST 241Am-Be SOURCE-MONTE CARLO SIMULATION AND MEASUREMENTS.

Neutron scatter contributions as a function of distance along the transverse axis of 241Am-Be source were estimated by three different methods such as shadow cone, semi-empirical and Monte Carlo. The Monte Carlo-based FLUKA code was used to simulate the existing room used for the calibration of CR-39 detector as well as LB6411 doseratemeter for selected distances from 241Am-Be source. The modified 241Am-Be spectra at different irradiation geometries such as at different source detector distances, behind the shadow cone, at the surface of the water phantom were also evaluated using Monte Carlo calculations.

Study on the measurement of photo-neutron for15 MV photon beam from medical linear accelerator under different irradiation geometries using passive detectors.

Aim Of Study: The photo-neutron dose equivalents of 15 MV Elekta precise accelerators were measured for different depths in phantom, for various field sizes, at different distances from the isocenter in the patient plane and for various wedged fields.

Materials And Methods: Fast and thermal neutrons are measured using passive detectors such as Columbia Resin-39 and pair of thermoluminescent dosimetry (TLD) 600 and TLD 700 detector from Elekta medical linear accelerator.

Results: It is found that fast photo-neutron dose rate decreases as the depth increases, with a maximum of 0.

Engaging patients using an interprofessional approach to shared decision making.

Many cancer treatment and screening decisions are difficult given that they rely upon patients' informed preferences. Interprofessional shared decision making is when two or more health care professionals collaborate with a patient to reach an agreed-upon decision. To support patients' engagement in shared decision making, effective interventions include patient decision aids and/or decision coaching.

Applications of a bis-urea phenylethynylene self-assembled nanoreactor for [2 + 2] photodimerizations.

Confined environments can be used to alter the selectivity of a reaction by influencing the organization of the reactants, altering the mobility of trapped molecules, facilitating one reaction pathway or selectively stabilizing the products. This manuscript utilizes a series of potentially photoreactive guests to interrogate the utility of the one-dimensional nanochannels of a porous host to absorb and facilitate the reaction of encapsulated guests. The host is a columnar self-assembled phenylethynylene bis-urea macrocycle, which absorbs guests, including coumarin, 6-methyl coumarin, 7-methyl coumarin, 7-methoxy coumarin, acenaphthylene, cis-stilbene, trans-stilbene, and trans-β-methylstyrene to afford crystalline inclusion complexes.

A randomized double-blind placebo-controlled clinical study on the effects of gabapentin premedication on hemodynamic stability during laparoscopic cholecystectomy.

Background: Carbon dioxide pneumoperitoneum for laparoscopic surgery increases arterial pressures, heart rate, and systemic vascular resistance. In this randomized double-blind placebo-controlled clinical study, we investigated the efficacy of gabapentin premedication to provide perioperative hemodynamic stability in patients undergoing laparoscopic cholecystectomy.

Materials And Methods: Sixty patients, of either sex (18-65 years of age) undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups of 30 patients each.

Kawasaki disease: a case report every otolaryngologist should know.

Kawasaki disease is the acute febrile vasculitis of childhood, predominantly affecting medium sized arteries with predilection for coronary arteries. The diagnosis is mainly clinical, though investigations are helpful in early detection of complications. We report a case of Kawasaki disease in a 5 year old child who presented to our hospital with conjunctival congestion, lymphadenopathy and fever.

Instructional scaffolding to improve students' skills in evaluating clinical literature.

Objective: To implement and assess the effectiveness of an activity to teach pharmacy students to critically evaluate clinical literature using instructional scaffolding and a Clinical Trial Evaluation Rubric.

Design: The literature evaluation activity centered on a single clinical research article and involved individual, small group, and large group instruction, with carefully structured, evidence-based scaffolds and support materials centered around 3 educational themes: (1) the reader's awareness of text organization, (2) contextual/background information and vocabulary, and (3) questioning, prompting, and self-monitoring (metacognition).

Assessment: Students initially read the article, scored it using the rubric, and wrote an evaluation.

Do pencil-point spinal needles decrease the incidence of postdural puncture headache in reality? A comparative study between pencil-point 25G Whitacre and cutting-beveled 25G Quincke spinal needles in 320 obstetric patients.

Background: Postdural puncture headache (PDPH) is a distressing complication of the subarachnoid block. The previous studies conducted, including the recent ones, do not conclusively prove that pencil-point spinal needles decrease the incidence of PDPH. In this study, we have tried to find out whether a pencil-point Whitacre needle is a better alternative than the classic cutting beveled, commonly used, Quincke spinal needle, in patients at risk of PDPH.

A comparative study between palonosetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy.

Background: Postoperative nausea and vomiting (PONV) is commonly seen after laparoscopic surgery. In this randomized double blind prospective clinical study, we investigated and compared the efficacy of palonosetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy. PATIENTS #ENTITYSTARTX00026;

Methods: Sixty female patients (18-65 yrs of age) undergoing elective laparoscopic cholecystectomy were randomly allocated one of the two groups containing 30 patients each.

Self-assembled phenylethynylene bis-urea macrocycles facilitate the selective photodimerization of coumarin.

There is much interest in designing molecular sized containers that influence and facilitate chemical reactions within their nanocavities. On top of the advantages of improved yield and selectivity, the studies of reactions in confinement also give important clues that extend our basic understanding of chemical processes. We report here, the synthesis and self-assembly of an expanded bis-urea macrocycle to give crystals with columnar channels.