Assignment of oxime and hydrazone configuration using H- N and C- N coupling measurements at natural abundance.

Measurement of H- N and C- N coupling constants at natural abundance is demonstrated to be a reliable and generic method to determine the configuration of oximes, hydrazines, and related systems. Data on H- N and C- N coupling constants on a variety of systems obtained at natural abundance confirm the geometric dependence of the measured H- N and C- N coupling constants. In addition, we summarize a simple "decision-tree" for determining configuration based on practical considerations of sample quantity, solubility, and complexity.

Effect of heated humidification on compliance and quality of life in patients with sleep apnea using nasal continuous positive airway pressure.

Study Objective: To determine whether the addition of heated humidification at treatment initiation with nasal continuous positive airway pressure (CPAP) would lead to better CPAP compliance and improve quality of life and subjective sleepiness in patients with sleep apnea.

Design: Randomized controlled trial.

Setting: An academic sleep center located at a Veterans Affairs hospital.