Publications by authors named "Dawn M R Davis"
Background: Controversy exists around the optimal timing of resection of nevus sebaceous (NS). The authors aim to determine optimal timing of NS resection and identify predictors of surgical outcomes and secondary intralesional neoplasms.
Methods: Retrospective chart review of all patients with biopsy-proven NS diagnosis treated at the authors' institution between 1987 and 2024.
Purpose: To review cases of lateral brow dermoid cysts and gain insight into the utility of preoperative imaging, incidence of intraorbital extension, and recurrence rate.
Methods: This is a retrospective study of all patients who underwent excision of lateral brow dermoid cysts at the authors' academic center over a 37-year period.
Results: A total of 136 patients were included.
Imaging Yield and Surgical Outcomes of Nasal, Medial Brow, Forehead, and Scalp Dermoid Cysts.
Cleft Palate Craniofac J
November 2024
Objective: Dermoid cyst (DC) is a congenital cyst with the potential to have intracranial extension (ICE). This study aims to evaluate the imaging yield and surgical outcomes of nasal, medial brow, forehead, and scalp DCs.
Design: Retrospective review of craniofacial DCs treated at our institution between 1992 and 2024.
An 11-year-old female was referred from an outside institution after a diagnostic biopsy and subsequent excision of a progressively enlarging reddish-brown nodule demonstrated features concerning for a balloon cell nevus with severe atypia versus a high-grade melanocytoma. Upon review of the initial biopsy specimen and molecular data, we favored the diagnosis to be consistent with a high-grade melanocytoma with balloon cell changes while considering the possibility of balloon cell melanoma due to concerning histopathologic and genetic abnormalities. In this case study, we discuss critical diagnostic considerations in this rare pediatric case and highlight important pathologic and clinical features of melanocytomas and balloon cell melanoma.
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- Linear IgA bullous dermatosis (LABD) is a rare autoimmune skin disorder found in both children and adults, characterized by blistering.
- A study at a large medical center reviewed 10 pediatric patients, noting common symptoms like the "cluster of jewels" sign in 60% of cases and mucous membrane involvement in 50%.
- Findings indicate that LABD in children can lead to significant health issues, with a majority requiring hospitalization, particularly those affected by mucous membrane symptoms.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is a rare autoimmune disorder that can be caused by medications or associated with malignancies; this study aimed to identify differentiating characteristics in patients with idiopathic, drug-induced, or malignancy-related LABD.
- A total of 81 patients were studied, revealing that those with drug-induced or malignancy-associated LABD had a significantly shorter disease duration and quicker diagnosis and improvement compared to idiopathic cases.
- The findings suggest the importance of screening for underlying health issues like malignancy or inflammatory bowel disease in newly diagnosed LABD patients, although the study had limitations such as retrospective data collection and lack of diverse participants.
Article Synopsis
- Updated guidelines revise the 2014 recommendations for managing atopic dermatitis (AD) using phototherapy and systemic therapies.
- A multidisciplinary team systematically reviewed evidence and used the GRADE approach to create 11 recommendations for adult AD management.
- Strong support was found for biologic and immunomodulatory treatments like dupilumab and abrocitinib, while phototherapy and certain medications received conditional support, and systemic corticosteroids were not recommended.
Article Synopsis
- The text discusses updated guidelines for treating atopic dermatitis (AD) in adults, particularly using phototherapy and systemic therapies since multiple new treatments were approved after 2014.* -
- A multidisciplinary workgroup established 11 evidence-based recommendations, emphasizing strong support for biologics and oral JAK inhibitors, while recommending caution with systemic corticosteroids.* -
- Limitations in the review highlight that many trials are short-term, which hampers the assessment of long-term effectiveness and safety for these treatments.*
Article Synopsis
- Pathologists play a crucial role in understanding skin changes during pregnancy, offering insights that enhance dermatological care for pregnant patients.
- The article categorizes dermatopathology updates into four main areas: normal skin changes, specific pregnancy-related skin disorders, conditions that change during pregnancy, and skin tumors that may arise.
- Recognizing these skin effects is essential for pathologists, as it improves diagnostic accuracy and patient care for pregnant individuals.
Article Synopsis
- Follicular mucinosis (FM) is a rare skin condition involving mucin buildup, often seen in children, with debates about its causes and potential for becoming malignant.
- A study investigated the long-term health outcomes of 14 pediatric patients diagnosed with FM, collecting data on their diagnosis, treatments, and health status.
- The results showed that none of the patients developed mycosis fungoides or other blood cancers, suggesting that FM in children is typically benign.
Article Synopsis
- Researchers created a clinical scoring system to differentiate between pemphigoid gestationis (PG) and polymorphic eruption of pregnancy (PEP), as they have different risks for mothers and babies.
- The scoring system was tested in a multicenter study featuring 16 cases of PG and 39 cases of PEP, showing significant differences in their scores.
- While the study is limited by its small size, the scoring system could be beneficial in settings with limited access to diagnostic testing.
Background: New evidence has emerged since the 2014 guidelines that further informs the management of atopic dermatitis (AD) with topical therapies. These guidelines update the 2014 recommendations for management of AD with topical therapies.
Objective: To provide evidence-based recommendations related to management of AD in adults using topical treatments.
These guidelines update the 2014 recommendations for management of atopic dermatitis in adults with topical therapies. A multidisciplinary workgroup employed best practices for guideline development, including a systematic review of the evidence and application of the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of the evidence and formulating and grading recommendations. The evidence on atopic dermatitis treatment supported strong recommendations for the use of nonprescription moisturizers, topical calcineurin inhibitors, topical corticosteroids, and topical PDE-4 and JAK inhibitors.
View Article and Find Full Text PDFBackground/objectives: Pediatric lichen planus (LP) is rare with variable prevalence and atypical presentations compared to adults. Data on LP are lacking for the pediatric population in the United States. We present demographics, presentations, and treatments for a pediatric LP cohort.
View Article and Find Full Text PDFUnlabelled: Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity disorder characterized by recurring dermatologic manifestations during the luteal phase of the menstrual cycle in women. Well-defined clinical and diagnostic criteria, outcomes measurements, and standard treatments are lacking.
Methods: We performed a single-institution retrospective review of adult patients (older than 20 years at the time of diagnosis) with APD.
Background/objectives: Basal cell nevus syndrome (BCNS) is an autosomal dominant skin cancer predisposition syndrome associated with abnormal mineral metabolism, a risk factor for urinary stone disease (USD). However, no research investigating the association between BCNS and USD or other manifestations of abnormal mineral metabolism has been conducted. The objective of this study is to investigate the association between BCNS and conditions associated with disordered mineral metabolism including USD, hypothyroidism, and osteoporosis and compare them to prevalence in the general population to elucidate potential unknown manifestations of the condition.
View Article and Find Full Text PDFBackground: Studies found associations between atopic dermatitis (AD) and various comorbidities.
Objective: To appraise evidence of the association between AD and comorbidities among adults.
Methods: Our multidisciplinary work group conducted a systematic review of the association between AD and selected comorbidities.
Background/objective: Current knowledge about usage of effective, but non-first-line topical acne medications in the United States is limited. We aimed to investigate utilization patterns and temporal trends for such acne medications in the US ambulatory care.
Methods: Pediatric (≤18 years old) and adult (>18 years old) data from the 2012 to 2016 (inclusive) cycles of the US National Ambulatory Medical Care Survey were extracted.