Moxidectin toxicosis in a puppy successfully treated with intravenous lipids.

Objective: To describe successful treatment of canine moxidectin toxicosis with the novel therapy of IV lipid administration.

Case Summary: A 16-week-old female Jack Russell Terrier was presented with acute onset of seizures followed by paralysis and coma shortly following suspected exposure to an equine formulation of moxidectin. Moxidectin toxicity was later confirmed.

Effect of meloxicam and carprofen on renal function when administered to healthy dogs prior to anesthesia and painful stimulation.

Objective: To determine whether administration of the nonsteroidal anti-inflammatory drugs meloxicam or carprofen to healthy dogs that were subsequently anesthetized and subjected to painful electrical stimulation has adverse effects on renal function as measured by glomerular filtration rate (GFR) and evaluation of serum concentrations of urea and creatinine.

Animals: 6 male and 6 female healthy young-adult Beagles.

Procedure: A study was conducted in accordance with a randomized crossover Latin-square design.