A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of ingestion in healthy adults.

Bis-hexanoyl (R)-1,3-butanediol (BH-BD) is a novel ketone ester that, when consumed, is hydrolyzed into hexanoic acid (HEX) and (R)-1,3-butanediol (BDO) which are subsequently metabolized into beta-hydroxybutyrate (BHB). We undertook a randomized, parallel, open-label study in healthy adults ( = 33) to elucidate blood BHB, HEX and BDO concentrations for 8 h following consumption of three different serving sizes (SS) of BH-BD (12.5, 25 and 50 g/day) before (Day 0) and after 7 days of daily BH-BD consumption (Day 7).

Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.

Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) or exogenous ketone consumption.

Trajectory of Weight Patterns in Urban Youth Throughout Their Stay in a Juvenile Justice System.

Incarceration is associated with health risks including overweight and obesity. This study explored obesity rates and weight gain in incarcerated youth by tracking weight trajectory during continuous stays in juvenile justice facilities. Among 65 youth, mean weight gain was 17.

Weight patterns of youth entering an urban juvenile justice facility.

Adolescents with a history of incarceration face a disproportionate number of health issues compared with their peers in virtually all areas, including perceived well-being; self-esteem; acute, chronic, and psychosocial disorders; and physical activity. Some studies have shown correlates of weight status and incarceration; however, the literature is conflicting. The current study sought to assess weight patterns of primarily minority urban youth (N = 548) entering a juvenile justice facility as well as associations between medications and weight status.

Low incidence of complications in asthmatic patients treated with preoperative corticosteroids.

The purpose of this study is to establish the incidence of perioperative complications in asthmatic patients treated with preoperative corticosteroids and to compare these rates to the general surgical population at the same hospital. Using a retrospective cohort design, we studied 172 patients who underwent 249 procedures at our hospital between 1986 and 2002. Preoperative corticosteroids were administered in 240 of the procedures.