Detection of DNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosis.

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Detection of complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study.

Background: Haematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for complex bacilli during latent tuberculosis infection. Our aim was to determine whether complex DNA is detectable in CD34-positive peripheral blood mononuclear cells (PBMCs) isolated from asymptomatic adults living in a setting with a high tuberculosis burden.

Methods: We did a cross-sectional study in Ethiopia between Nov 22, 2017, and Jan 10, 2019.