Implant-based direction of magnetic nanoporous silica nanoparticles - influence of macrophage depletion and infection.

Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg.

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics.

Background: In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibiotics, and still often fail. Drug-loaded magnetic nanoparticles are very promising for local selective therapy, enabling lower systemic antibiotic doses and reducing adverse side effects.

Nanoporous hybrid core-shell nanoparticles for sequential release.

In this article, a new type of core-shell nanoparticle is introduced. In contrast to most reported core-shell systems, the particles presented here consist of a porous core as well as a porous shell using only non-metal materials. The core-shell nanoparticles were successfully synthesized using nanoporous silica nanoparticles (NPSNPs) as the starting material, which were coated with nanoporous phenylene-bridged organosilica, resulting in a total particle diameter of about 80 nm.

A Low-Temperature Approach for the Phase-Pure Synthesis of MIL-140 Structured Metal-Organic Frameworks.

In a systematic investigation, the synthesis of metal-organic frameworks (MOFs) with MIL-140 structure was studied. The precursors of this family of MOFs are the same as for the formation of the well-known UiO-type MOFs although the synthesis temperature for MIL-140 is significantly higher. This study is focused on the formation of Zr-based MIL-140 MOFs with terephthalic acid (H bdc), biphenyl-4,4'-dicarboxylic acid (H bpdc), and 4,4'-stilbenedicarboxylic acid (H sdc) and the introduction of synthesis field diagrams to discover parameters for phase-pure products.

Macrophage entrapped silica coated superparamagnetic iron oxide particles for controlled drug release in a 3D cancer model.

Targeted delivery of drugs is a major challenge in treatment of diverse diseases. Systemically administered drugs demand high doses and are accompanied by poor selectivity and side effects on non-target cells. Here, we introduce a new principle for targeted drug delivery.

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties.

Background: In orthopedic surgery, implant-associated infections are still a major problem. For the improvement of the selective therapy in the infection area, magnetic nanoparticles as drug carriers are promising when used in combination with magnetizable implants and an externally applied magnetic field. These implants principally increase the strength of the magnetic field resulting in an enhanced accumulation of the drug loaded particles in the target area and therewith a reduction of the needed amount and the risk of undesirable side effects.