The study examines the prevalence of the Hb S gene and its haplotypes among the ethnically diverse population in the Jazan area of Saudi Arabia, focusing on sickle-cell anemia cases.
Data from 5,990 participants showed that 86.8% were Hb AA, 12.4% were Hb AS, and only 0.8% were Hb SS, indicating a low prevalence of sickle cell disease.
Among 70 sickle cell patients and a control group of 30 healthy individuals, new findings suggested a possible new haplotype, [±] Xmn1 '5 to G, with most patients exhibiting high levels of Hb F, which is usually linked to low Hb F levels.