LncRNA MIAT suppresses inflammation in LPS-induced J774A.1 macrophages by promoting autophagy through miR-30a-5p/SOCS1 axi.

Accumulated data implicate that long noncoding RNA (lncRNA) plays a pivotal role in rheumatoid arthritis (RA), potentially serving as a competitive endogenous RNA (ceRNA) for microRNAs (miRNAs). The lncRNA myocardial infarction-associated transcript (MIAT) has been demonstrated to regulate inflammation. However, the role of MIAT in the inflammation of RA remains inadequately explored.

Origin of the Cr concentration-dependent broadband near-infrared emission in ScSiO.

The challenge of developing phosphors with tailored near-infrared (NIR) emission ranges to meet the diverse demands of various applications is a paramount concern in the contemporary realm of NIR phosphor research. A strong dependence of NIR emission on Cr concentration has been demonstrated in ScSiO:Cr, which exhibits an NIR emission band at 840 nm for low Cr doping concentrations ( = 0.001-0.

Thermal stability and quantum efficiency improvement of Cr-activated garnet phosphors regulating A/B sites for near-infrared LED applications.

The discovery of phosphors with highly efficient broadband near-infrared emission is urgent for constructing NIR sources for various applications. Herein, we synthesized a series of near-infrared emitting garnet-type (ABCO) LuCaAlCrSiO:Gd/La and LuCaAlCrSiO:Sc/Ga phosphors and systematically investigated the effect of A/B-site substitution on the crystal structure and luminescence properties. Structural and optical analyses revealed that the A/B-site substitution weakened the crystal field strength, further enhancing the broadband emission of the allowed T → Atransition and diminishing the narrow-peak emission of the forbidden E → A transition.

Frontiers in the Etiology and Treatment of Preterm Premature Rupture of Membrane: From Molecular Mechanisms to Innovative Therapeutic Strategies.

Preterm premature rupture of membranes (pPROM) poses a significant threat to fetal viability and increases the risk for newborn morbidities. The perinatal period of preterm infants affected by pPROM is often characterized by higher rates of mortality and morbidity, with associated risks of cerebral palsy, developmental delays, compromised immune function, respiratory diseases, and sensory impairments. pPROM is believed to result from a variety of causes, including but not limited to microbially induced infections, stretching of fetal membranes, oxidative stress, inflammatory responses, and age-related changes in the fetal-placental interface.

Quantifying rigidity for thermally stable Cr phosphors.

Near-infrared (NIR) phosphors with high thermal stability are significant for NIR light-emitting diodes (LEDs). For a decade, Debye temperature has been a successful indicator of structural rigidity and thermal stability for phosphors, but some exceptions exist due to its dependence on atomic mass. Inspired by the Debye temperature model that relates the elastic properties of solids, our density functional theory calculations revealed that the Vickers hardness of Cr-doped NIR phosphors was negatively correlated with Stokes shifts (Pearson's = -0.

Improved Thermal and Chemical Stability of Oxynitride Phosphor from Facile Chemical Synthesis for Vehicle Cornering Lights.

Orange Eu -doped phosphors are essential for light-emitting diodes for cornering lights to prevent fatal road accidents at night, but such phosphors require features of high thermal, chemical stability and facile synthesis. This study reports a series of yellow-orange-red emitting SrAl Si ON :Eu oxynitride phosphors, derived from the SrAlSi N nitride iso-structure by replacing Si -N with Al -O . The introduction of a certain amount of oxygen enabled the facile synthesis under atmospheric pressure using the air-stable raw materials SrCO , Eu O , AlN and Si N .

Tetrahedrally coordinated rigid crystal structure enables partial self-reduction of mixed-valence europium for optical thermometric application.

Mixed-valence europium-activated phosphors are receiving attention in many fields, such as lighting, anti-counterfeiting, optical recording, encryption, and temperature sensing. However, it remains difficult to construct mixed-valence europium-activated compounds due to the reductive and oxidative synthesis conditions required to obtain Eu and Eu ions, respectively. Herein, mixed-valence Eu/Eu was realized in the CaBPO built by rigidly connected BO and PO tetrahedrons by partial Eu → Eu self-reduction in the air atmosphere.

Near-UV excited multifunctional near-infrared phosphors for anti-counterfeiting and ratiometric thermometer applications.

Considerable efforts have been devoted to the development of visible light-emitting phosphors for anti-counterfeiting application, but the design of multifunctional near-infrared materials with suitable luminescent properties was lacking. Based on the crystal field theory, a near ultraviolet excitable and near-infrared emitting CaSnAlO:2Cr,2Si phosphor was designed. On the one hand, the CaSnAlO:2Cr,2Si phosphor showed great potential for applications including anti-counterfeiting and secret signals under a 405 nm near UV laser.

Disorder-Order Conversion-Induced Enhancement of Thermal Stability of Pyroxene Near-Infrared Phosphors for Light-Emitting Diodes.

The minimization of thermal quenching, which leads to luminescence loss at high temperatures, is one of the most important issues for near-infrared phosphors. In the present work, we investigated the properties of near-infrared Ca(Sc,Mg)(Al, Si)O  : Cr phosphors with a pyroxene-type structure under blue light excitation. The CaScAlSiO  : Cr end member of Ca(Sc,Mg)(Al,Si)O  : Cr phosphor led to broadband emission at a full-width half maximum of 215 nm, whereas the CaMgSi O  : Cr end member exhibited high thermal stability at 150 °C, with an intensity of 88.

Erythropoiesis signature and ubiquitin-mediated proteolysis are enriched in systematic juvenile idiopathic arthritis.

Systemic Juvenile Idiopathic Arthritis (sJIA) is a distinctive subtype of Juvenile Idiopathic Arthritis (JIA). The pathogenesis of sJIA is still unclear with the limited treatment options. Although previous bioinformatics analyses have identified some genetic factors underlying sJIA, these studies were mostly single centre with a small sample size and the results were often inconsistent.

Monitoring ecosystem services in the Guangdong-Hong Kong-Macao Greater Bay Area based on multi-temporal deep learning.

Assessment of ecosystem service supply and demand, as well as the budgets of ecosystem service supply and demand, is the basis of scientific urban planning. In the 20 years between the proposal and formation of the Guangdong-Hong Kong-Macao Greater Bay Area (GBA), the natural ecosystem has been degraded and the ecological balance has been destroyed. In this paper, in order to assess the changes in ecosystem services in the GBA, a deep learning method composed of deep change vector analysis and the ResUnet model is proposed to achieve land use/land cover (LULC) mapping for 2000 and 2020.

LncRNA MIAT downregulates IL-1β, TNF-ɑ to suppress macrophage inflammation but is suppressed by ATP-induced NLRP3 inflammasome activation.

Cardiovascular disease (CVD) has been identified as the leading cause of premature deaths in rheumatoid arthritis (RA), accounting for about 40 to 50% of all deaths. Macrophage inflammation is regarded as a key point to link to the two diseases. Recently, long non-coding RNAs (lncRNAs) have acknowledged as a regulator of inflammation significantly.

A simple and efficient approach toward deep-red to near-infrared-emitting iridium(iii) complexes for organic light-emitting diodes with external quantum efficiencies of over 10.

While the external quantum efficiency (EQE) of iridium(iii) (Ir(iii)) phosphor based near-infrared organic light-emitting diodes (NIR OLEDs) has been limited to 5.7% to date, there is no significant EQE improvement for these types of OLEDs due to the lack of efficient Ir(iii) emitters. Here, a convenient approach within three synthetic steps is developed to afford two novel and efficient deep-red to near-infrared (DR-NIR) emitting phosphors ( and ), in which a cyano group is added into a commercial red emitter named to significantly stabilize the lowest unoccupied molecular orbitals of the newly designed Ir(iii) complexes.

Mirt2 functions in synergy with miR-377 to participate in inflammatory pathophysiology of Sjögren's syndrome.

The interaction of long non-coding RNAs (lncRNAs)-microRNAs (miRs) exerts crucial functions in mediating inflammatory reaction. It is still unclear whether myocardial infarction associated transcript 2 (Mirt2)-miR-377 mediates the inflammatory pathogenesis in Sjögren's syndrome (SS). The inflammatory lesion model was established by stimulating salivary gland epithelial cells (SGECs) by interferon gamma (IFN-γ).

[Establishment of human B lymphocyte strain overexpressing Epstein-Barr virus latent membrane protein 1 (LMP1)].

Objective To establish a human B lymphoma cell line which can stably express Epstein-Barr virus latent membrane protein 1 (LMP1). Methods The LMP1 coding gene with EcoRI and BamHI restriction sites was amplified, cloned into pcDNA3.1-EF1a-mcs-3FLAG-CMV-EGFP plasmid, and positive monoclonal competent cells were picked for PCR and sequencing.

Ce-Based Compounds Capable of Photoluminescence by Charge Transfer Excitation under Near-Ultraviolet-Visible Light.

Ce-based charge transfer phosphor is not common and has been reported mainly in SrCeO with an excitation band peaking at ∼290 nm, mismatching with the near-ultraviolet light emitting diodes. Herein, we report a new series of Ce-based compounds SrCeREZnO (RE = Y, La, and Eu) capable of photoluminescence induced by O-Ce charge transfer excitation under near-ultraviolet-visible light. The crystal structure of SrCeEuZnO was determined by single crystal X-ray diffraction.

Anomalous Orange Light-Emitting (Sr,Ba)2SiO4:Eu(2+) Phosphors for Warm White LEDs.

Phosphors with sufficient red emission component are necessary for warm white light-emitting diodes. In this work on (Sr,Ba)2(1-x)Eu2xSiO4 phosphors, (Sr,Ba)1.5Eu0.

Adult Common Variable Immunodeficiency.

Background: Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, defective antibody production and recurrent upper and lower respiratory tract infections. The diagnosis in adult patients is often thought to be rare, and thus misdiagnosis often occurs. A limited number of cases of adult-onset CVID have been reported in China, and the features of the syndrome remain unclear.

Studies of terbium bridge: saturation phenomenon, significance of sensitizer and mechanisms of energy transfer, and luminescence quenching.

Terbium chain in the form of S → (Tb(3+))n → A (S = Ce(3+) or Eu(2+), A = Eu(3+)), as a promising energy transfer (ET) approach, has been proposed to enhance Eu(3+) emission for solid-state lighting. However, the viewpoint of ET from S to A via the terbium chain (Tb(3+)-Tb(3+)-Tb(3+)-..

A novel narrow-line red emitting Na2Y2B2O7:Ce(3+),Tb(3+),Eu(3+) phosphor with high efficiency activated by terbium chain for near-UV white LEDs.

The application of white LEDs is hindered by the low efficiency of commercial red phosphors. Here, a novel narrow-line red phosphor is produced by a terbium chain in the form of Ce(3+)-(Tb(3+))n-Eu(3+) in the Na2Y2B2O7 host and is characterized with X-ray diffraction, photoluminescence (PL), PL excitation (PLE), and fluorescence lifetime, and the energy transfer (ET) processes between rare-earth ions in the host are discussed. The formation of terbium chain with a quite low content of Tb(3+) in Na2Y2B2O7 is realized by the ET processes of Ce(3+)-Tb(3+) and Tb(3+)-Eu(3+), and a new concept of saturation distance is put forward as an explanation for the first time.

Aquareovirus protein VP6 colocalizes with NS80 protein in infected and transfected cells.

Background: Aquareovirus particle is comprised of central core and outer capsid, which is built by seven structural proteins (VP1-VP7). The protein VP6 has been identified to be a clamp protein of stabilizing inner core frame VP3, and bridging outer shell protein VP5. However, the biological properties of VP6 in viral life cycle remain unknown.

Synergistic design of electric field and membrane in facilitating continuous adsorption for cleanup and enrichment of proteins in direct ESI-MS analysis.

We designed and fabricated a novel microdevice to facilitate continuous adsorption phenomena for biological sample preparation. Using the device, we also developed an online, highly integrated, multifunctional strategy, with a promise of accepting a large volume of crude tissue extracts with the end point generation of a reliable MS identification within 20 min. Under an external electric field, charged membranes can adsorb multiple layers of proteins, which exceed the capacity limit of common resins or membranes.

Rapid determination of C12-C26 non-derivatized fatty acids in human serum by fast gas chromatography.

The concentration of long-chain fatty acids (LCFAs) in human serum is closely related to human health. It is therefore important to develop a fast, low-cost, efficient method for their determination. In this study, by using fast temperature programming and micro-bore short capillary columns, a fast gas chromatography method was developed for the direct analysis of non-derivatized LCFAs including n-dodecanoic acid to n-hexacosanic acid (C12:0-C26:0, even numbers only), linoleic acid (C18:2), oleic acid (C18:1), and erucic acid (C22:1) within 4.

[Determination of underivatized long-chain fatty acids in edible oils by fast gas chromatography].

A fast gas chromatography (GC) method with short micro-bore capillary column was developed for the determination of underivatized long-chain fatty acids (LCFAs) in edible oils. Baseline separation of eight kinds of LCFAs (dodecanoic acid, tetradecanoic acid, palmitic acid, oleic acid, stearic acid, eicosanic acid, erudcic acid, behenic acid) was achieved within 2 min with high resolution performance. The linear correlation coefficients for underivatized LCFAs were higher than 0.