Publications by authors named "Dawei Gong"

Background: Selective antimicrobial effects have been found for α1,4-linked N-acetylglucosamine residues at the terminus of O-glycans attached to a core protein of gastric gland mucin. encodes α1,4-N-acetylglucosaminyl transferase, which is responsible for the biosynthesis of α1,4-linked N-acetylglucosamine. The impact of A4GNT on the establishment and homeostasis of the gastric microbiome remains to be clarified.

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Osteoarthritis (OA) is a multi-factorial degenerative joint disease with unclear pathogenesis. Conservative treatments, primarily aimed at pain relief, fail to halt disease progression. Metabolic syndrome has recently been implicated in OA pathogenesis, underscoring the need for novel therapeutic strategies.

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A visible-light-induced method for the hydrodichloromethylation of unactivated alkenes using chloroform (CHCl) was developed, employing pyridine·BH as the halogen atom transfer (XAT) reagent. The strategy showed a broad functional group tolerance, and 29 examples of unactivated alkenes, including complex natural products or drug derivatives, have been established with good yields. Mechanistic studies indicated that CHCl serves as both the source of a dichloromethyl radical and a hydrogen atom transfer (HAT) reagent, and the borane short-chain reaction process was involved in this system.

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Article Synopsis
  • - The study developed a snapshot computed tomographic microscopic imaging spectrometer (CTMIS) to improve the speed and efficiency of spectral imaging compared to conventional methods, which take longer to scan across wavelengths or spatial dimensions.
  • - Using the CTMIS-UNET algorithm, researchers reconstructed high-resolution spectral data (541x541x26) from micro spectral imaging videos, achieving resolutions of under 4 μm spatially and better than 10 nm spectrally, with high accuracy in comparison to ground truth data.
  • - The system successfully captured images of various algae species in under 10 ms, with a pixel-level recognition accuracy over 95% and cell counting accuracy over 85%, providing a powerful tool for real-time monitoring of harmful alg
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There is limited information regarding spatial and seasonal variations of atmospheric microplastics (MPs) and factors influencing MPs at the intersection of tropical and subtropical regions. A one-year study was conducted at sites in a high-population-density village (HPDV) and a low-population-density village (LPDV) in Taiwan to investigate the characteristics and influencing factors of airborne MPs. The predominant shapes, sizes, and polymer compositions of MPs were fragments, 3 to 25 and 26-50 μm, and polyamide at both sites.

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Background: Osteoarthritis (OA) is a common chronic age-related joint disease characterized primarily by inflammation of synovial membrane and degeneration of articular cartilage. Accumulating evidence has demonstrated that Danggui-Shaoyao-San (DSS) exerts significant anti-inflammatory effects, suggesting that it may play an important role in the treatment of knee osteoarthritis (KOA).

Methods: In the present study, DSS was prepared and analyzed by high-performance liquid chromatography (HPLC).

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This article aims to solve the optimal tracking problem (OTP) for a class of discrete-time (DT) nonlinear systems with completely unknown dynamics. A novel data-driven deterministic approximate dynamic programming (ADP) algorithm is proposed to solve this kind of problem with only input-output (I/O) data. The proposed algorithm has two advantages compared to existing data-driven deterministic ADP algorithms for the OTP.

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Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuClPPh() catalyst showed the best catalytic performance (0.5 mol %, 12 h).

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This study aimed to explore the effect of myricitrin on osteoblast differentiation in mice immortalised bone marrow mesenchymal stem cells (imBMSCs). Additionally, ovariectomy (OVX) mice were employed to examine the effect of myricitrin on bone trabecular loss in vivo. The effect of myricitrin on the proliferation of imBMSCs was evaluated using a cell counting kit-8 assay.

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A nickel-catalyzed semihydrogenation of azoarenes to hydrazoarenes with NHBH is developed. The catalytic system exhibits good functional group tolerance and a high turnover frequency at room temperature. Results of control and deuterium-labeling experiments indicate that the ethanol hydroxyl and BH groups each donated one hydrogen to this transfer hydrogenation, and the main byproducts were B(OEt) and H.

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Purpose: The aim of this study was to investigate the function and mechanisms of ELABELA (ELA) in the aerobic exercise-induced antiapoptosis and angiogenesis of ischemic heart.

Methods: The myocardial infarction (MI) model of Sprague-Dawley rat was established by the ligation of the left anterior descending coronary artery. MI rats underwent 5 wk of Fc-ELA-21 subcutaneous injection and aerobic exercise training using a motorized rodent treadmill.

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In this study, we propose a parallel processing method for analyzing video-image radiation-response signals and suppressing radiation noise. We studied the linear-representation law of various image-information components on the radiation dose rate. Subsequently, the simulation images were used to examine the response-signal extract and radiation-noise suppression.

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The transfer hydrogenation of azoarenes to hydrazoarenes using ethanol as a hydrogen source by a bidentate Ru(II)-NC complex is developed. A weak base is crucial for this semihydrogenation that can efficiently avoid hydrazoarene dehydrogenation under strongly basic conditions. Control experiments and density functional theory calculations demonstrate the mechanism via a Meerwein-Ponndorf-Verley mechanism, and the only byproduct is ethyl acetate.

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Apelin receptor (APJ) ligands elabela (ELA) and apelin have divergent distributions and function differently in vitro and in vivo. Whether differences exist in their capacity of recruitment of β-arrestins (ARRBs) to APJ remains unknown. The aim of the current study was to investigate the different effects of ELA and apelin on the interaction between APJ and ARRBs in live cells by NanoBiT®.

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Background: This study used original survey data to quantitatively investigate the associations between individuals’ perception of locally present wastewater pollution and their self-rated health. Methods: This research used the data from large-scale surveys covering all the 31 provinces and equivalent administrative units in mainland China and interviewed 6112 participants. The ordered logit method was employed to estimate the models.

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In this paper, a parallel Image-based visual servoing/force controller is developed in order to solve the interaction problem between the collaborative robot and the environment so that the robot can track the position trajectory and the desired force at the same time. This control methodology is based on the image-based visual servoing (IBVS) dynamic computed torque control and couples the force control feedback in parallel. Simulations are performed on a collaborative Delta robot and two types of image features are tested to determine which one is better for this parallel IBVS/force controller.

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Osteoporosis is a major health problem in the elderly. Almost every bone can fracture due to the increased bone fragility in osteoporosis, posing a major challenge to public health. 12-Deoxyphorbol-13-hexadecanoate (DHD), one of the main bioactive components of L.

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In this article, a novel model-free dynamic inversion-based Q-learning (DIQL) algorithm is proposed to solve the optimal tracking control (OTC) problem of unknown nonlinear input-affine discrete-time (DT) systems. Compared with the existing DIQL algorithm and the discount factor-based Q-learning (DFQL) algorithm, the proposed algorithm can eliminate the tracking error while ensuring that it is model-free and off-policy. First, a new deterministic Q-learning iterative scheme is presented, and based on this scheme, a model-based off-policy DIQL algorithm is designed.

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In this paper, we present an ultrawide-range radiation detection method based on dynamic recognition and analysis of the response signal of a monolithic active pixel sensor (MAPS). Our analysis of the MAPS response mechanism determined that adaptive adjustment of the sensor's integral time is key to quantification of ionizing radiation in an ultrawide range. We also determined that different data processing methods are required for accurate quantification of high and low radiation dose rates.

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Designing a robot with the best accuracy is always an attractive research direction in the robotics community. In order to create a Gough-Stewart platform with guaranteed accuracy performance for a dedicated controller, this paper describes a novel advanced optimal design methodology: control-based design methodology. This advanced optimal design method considers the controller positioning accuracy in the design process for getting the optimal geometric parameters of the robot.

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Herein, we report the γ-ray ionizing radiation response of a commercial monolithic active-pixel sensor (MAPS) camera under strong-dose-rate irradiation with an online detection and monitoring system for strong radiation conditions. We present the first results of the distribution of three types of MAPS camera and establish a linear relationship between the average response signal and radiation dose rate in the strong-dose-rate range. There is an obvious response signal in the video frames when the camera module parameters are set to automatic, but the linear response is very poor.

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We present γ-ray radiation detection in a neutron radiation environment using a monolithic active pixel sensor (MAPS) camera without conversion or shielding layers. The measured output signal is the sum of the pedestal value, noise, and real radiation response signal. The sensor response shows that the MAPS camera is sensitive to neutrons and can capture a single photon.

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Introduction: Renal ischemia/reperfusion injury (IRI) is the most common cause of acute kidney injury (AKI), and patients with AKI have a high rate of mortality. Apelin is a therapeutic candidate for treatment of IRI and Elabela (ELA) is a recently discovered hormone that also activates the apelin receptor (APJ). We examined the use of ELA as a preventive treatment for IRI using in vitro and in vivo models.

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Peroxisome proliferator-activated receptor-γ (PPARγ) is the master regulator of adipogenesis, but knowledge about how PPARγ is regulated at the protein level is very limited. We aimed to identify PPARγ-interacting proteins which modulate PPARγ's protein levels and transactivating activities in human adipocytes. We expressed Flag-tagged PPARγ in human preadipocytes as bait to capture PPARγ-associated proteins, followed by mass spectroscopy and proteomics analysis, which identified serine/threonine kinase 38 (STK38) as a major PPARγ-associated protein.

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Purpose: The aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1 (FSTL1), which may induce cardioprotection in rats following myocardial infarction (MI) by inducing angiogenesis.

Methods: Male, adult Sprague-Dawley rats were randomly divided into 5 groups (n = 12 in each group): sham group (S), sedentary MI group (MI), MI + resistance exercise group (MR), MI + adeno-associated virus (AAV)-FSTL1 injection group (MA), and MI + AAV-FSTL1 injection + resistance exercise group (MAR). The AAV-FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis muscle.

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