The neutrophil antigen 3a/b polymorphism in SLC44A2 unexpectedly encodes Csa/Csb red cell antigens.

The Csa blood group antigen was identified more than 50 years ago but its genetic basis has yet to be elucidated. All our recent genomic investigation has failed to resolve the genetic basis of this enigmatic antigen. By investigating the association of the HNA-3a/b polymorphism (rs2288904-G/A) in SLC44A2 with clinical features of Sickle Cell Disease (SCD), we incidentally discovered that rare subjects with the homozygous HNA-3b/b genotype also carry the uncommon Cs(a-) phenotype.

Risk of second primary cancer in young breast cancer survivors: an important yet overlooked issue.

Currently, female breast cancer (BC) represents the highest incidence of cancer globally. This trend has raised significant attention regarding breast cancer young women (BCYW). With advancements in treatment technology, BCYW survivors are living longer; however, the risk of developing or succumbing to a second primary cancer (SPC) has greatly increased.

Molecular profiling of skin cells identifies distinct cellular signatures in radiation-induced skin injury across various stages in the murine dataset.

Background: Radiation-induced skin injury (RISI) commonly manifests in cancer patients undergoing radiotherapy (RT). However, a universally accepted standard for treating radiation injury has not yet been established. Our objective was to provide a detailed molecular overview of skin pre- and post-radiation therapy, aiming to enhance our understanding of the subclusters and molecular mechanisms contributing to radiodermatitis.

Latent class analysis of autonomous vehicle crashes.

Introduction: Since September 2014, the California Department of Motor Vehicles has requested autonomous vehicle (AV) manufacturers to report their accidents if they take field tests on public roadways in California. These collision reports are heterogeneous containing a variety of accident factors.

Method: To describe the accident more elaborately, we add three new category variables: 'traffic control and status,' 'speed/speed change,' and 'type of accident location,' extracted from crash narratives.

Excessive lymph node dissection increases postoperative cardiovascular disease risk in non-small cell lung cancer patients.

Heart disease is the second leading cause of death in lung cancer (LC) patients, with postoperative cardiovascular disease (CVD) commonly linked to lymph node dissection (LND). This study aimed to clarify the optimal number of lymph nodes (LNs) to be dissected by investigating the impact of LND on CVD related death in patients with surgically resected non-small cell lung cancer (NSCLC). We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database for a total of 154,566 patients with stage IA-IIIA NSCLC that underwent curative surgery from 2000 to 2020, and further validated using clinical data from a single-center cohort.

The burden of COVID-19 death for different cancer types: a large population-based study.

Background: Viral mutations and immune dysfunction still lead to recurrent infections of COVID-19 in cancer patients. Our aim in this study was to explore the differences in cumulative risk of COVID-19 death from different cancer types and characterise clinical and demographic factors associated with COVID-19 death.

Methods: We conducted a population-based study using the National Cancer Database, which included all cancer types.

Research on the Enhancement of the Flotation of Low-Rank Coal Slime by Compound Collectors.

High-efficiency flotation of low-rank coal slime is an urgent problem to be solved in the comprehensive recycling and utilization of coal resources. The flotation results presented that the flotation effect of a single collector on low-rank coal slime was poor, which made it difficult to improve its flotation index. When dodecamine was added alone, the yield and ash of cleaned coal were higher at 79.

Thyroxine alleviates interstitial lung disease induced by combined radiotherapy and immunotherapy.

Immune checkpoint blockade (ICB) combined with radiotherapy (RT) has improved patients survival, but also increased the risk of pulmonary adverse effects (AEs). Therefore, to explore potential drug targets for interstitial lung disease (ILD). We investigated the interaction of ICB and RT in pulmonary AEs using the disproportionality analysis and COX regression.

The transcriptional regulation effects of histidine, isoleucine and glutamate on free exopolysaccharide biosynthesis of 937.

Introduction: The free exopolysaccharide (f-EPS) produced by is a natural texture modifier and has a variety of prebiotic activities. Our previous studies showed f-EPS production from 937 was increased 2-fold in the presence of 15 mM of glutamate, isoleucine, and histidine in the chemically defined medium.

Methods: In this study, we used transcriptomics and qPCR to further explore the specific mechanism of the enhanced effect of 3 amino acids on the f-EPS biosynthesis of 937.

CT-based scoring system for diagnosing eosinophilic solid and cystic renal cell carcinoma versus clear cell renal cell carcinoma.

Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is rare and often misdiagnosed as clear cell renal cell carcinoma (ccRCC). Therefore, a CT-based scoring system was developed to improve differential diagnosis. Retrospectively, 25 ESC-RCC and 176 ccRCC cases, were collected.

The Association Between Neutrophil-Percentage-to-Albumin Ratio (NPAR) and Mortality Among Individuals With Cancer: Insights From National Health and Nutrition Examination Survey.

Background: Neutrophils interact with tumor cells, potentially exacerbating cancer progression. Additionally, decreased albumin levels are a marker of poor cancer prognosis. The neutrophil-percentage-to-albumin ratio (NPAR) has been used for prognostic assessment in non-cancerous diseases, but its relationship with mortality risk in cancer patients has not been explored.

Endobutton plates demonstrate superior efficacy in treating unstable distal clavicle fractures.

Objective: To compare the effectiveness of clavicular hook plates and Endobutton plates in treating unstable distal clavicle fractures (UDCFs).

Methods: Data from 95 patients with UDCFs (Neer II and V types) were retrospectively analyzed. Among them, 55 cases were treated with clavicular hook plates (control group), and 40 cases with Endobutton plates (research group).

Melatonin attenuates BDE-209-caused spatial memory deficits in juvenile rats through NMDAR-CaMKⅡγ-mediated synapse-to-nucleus signaling.

Flame retardant polybrominated diphenyl ethers (PBDEs) accumulate in human bodies through food and dust ingestion, and cause neurobehavioral deficits with obscure mechanism. We aimed to investigate NMDAR-CaMKⅡγ-mediated synapse-to-nuclear communication involved in BDE-209-induced cognitive impairment, and alleviation from exogenous melatonin. Decreased NMDAR subunits GluN2A and 2B, autophosphorylation of CaMKⅡα, and postsynaptic GluA1 trafficking were observed in the hippocampus of juvenile rats after maternal BDE-209 exposure.

Occurrences of heavy metal in breast milk in China: Results of the third national breast milk survey.

To investigate the exposure of infants to heavy metal during lactation, breast milk from 24 provinces in China were detected. Among As, Cd, Cr, Hg, and Pb, the detection frequencies of As (85 %, 0.50 μg/L) and Cd (91 %, 0.

[Study of the feasibility of polar body transfer combined with preimplantation genetic testing for blocking the intergenerational transmission of mitochondrial genetic diseases].

Objective: To assess the feasibility of first polar body transfer (PB1T) combined with preimplantation mitochondrial genetic testing for blocking the transmission of a pathogenic mitochondrial DNA 8993T>G mutation.

Methods: A Chinese family affected with Leigh syndrome which had attended the Reproductive Medicine Centre of the First Affiliated Hospital of Anhui Medical University in September 2021 was selected as the study subject. Controlled ovarian hyperstimulation was carried out for the proband after completing the detection of the mitochondrial DNA 8993T>G mutation load among the pedigree members.

Longitudinal single-cell RNA sequencing reveals a heterogeneous response of plasma cells to colonic inflammation.

A comprehensive understanding of the dynamic changes in plasma cells (PCs) during inflammation remains elusive. In this study, we analyzed the distinct responses of PCs across different phases of inflammation in a dextran sodium sulfate (DSS)-induced mouse colitis model. Six-week-old male C57BL/6 mice were treated with 2.

A Machine Learning-Based Prediction Model for Acute Kidney Injury in Patients With Community-Acquired Pneumonia: Multicenter Validation Study.

Background: Acute kidney injury (AKI) is common in patients with community-acquired pneumonia (CAP) and is associated with increased morbidity and mortality.

Objective: This study aimed to establish and validate predictive models for AKI in hospitalized patients with CAP based on machine learning algorithms.

Methods: We trained and externally validated 5 machine learning algorithms, including logistic regression, support vector machine, random forest, extreme gradient boosting, and deep forest (DF).

Association of serum klotho level with albuminuria in middle‑aged and elderly participants without diabetes mellitus: a cross‑sectional study.

Background: The relationship between serum klotho level and albuminuria is unknown in middle-aged and elderly participants without diabetes mellitus (DM). Therefore, we will investigate the association between serum klotho level and albuminuria in middle-aged and elderly participants without DM.

Methods: Participants (aged 40-79) were from the five continuous cycles (2007-2016) of the National Health and Nutrition Examination Survey (NHANES).

for the Preparation of Fermented Low-Bitter Enzymatic Skim Milk with Antioxidant Ability.

A high degree of hydrolysis can reduce the allergenicity of milk, while lactic acid bacteria (LAB) fermentation can further enhance the antioxidant ability of enzymatic milk. LAB with a strong antioxidant ability was screened, and the effects of LAB on the bitterness, taste and flavor of enzymatic skim milk (ESM) with a high degree of hydrolysis were investigated in this paper, in addition to the response surface methodology optimized the conditions of the LAB fermentation of ESM. The results indicate that the skim milk hydrolyzed by Protamex has a higher degree of hydrolysis and lower bitterness.

The impact of POSTN on tumor cell behavior and the tumor microenvironment in lung adenocarcinoma.

Background: The role of cancer-associated fibroblasts (CAFs) in modulating the anti-tumor immune response in lung adenocarcinoma (LUAD) remains elusive, primarily due to the heterogeneous nature of these cells. This heterogeneity muddles the understanding of their impact on immunotherapy effectiveness.

Methods: We utilized the LUAD single-cell dataset to precisely classify tumor cells and CAFs.

KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway.

In our present study, we investigated the interaction between HSCs and HCC, also explored the molecular mechanism. Clinical samples were collected from HCC and adjacent tissue with different degree of liver fibrosis. HCC cells were co-cultured with LX-2 cell by Transwell system or cultured with conditioned medium (CM), which was collected from LX-2.

Prebiotics enhance the immunomodulatory effect of DALI02 by regulating intestinal homeostasis.

The colonization ability of DALI02 and the promoting effect of fermented prebiotics have been studied. This study aims to evaluate the systemic immunomodulatory effects of DALI02 and DALI02 + Prebiotics on cyclophosphamide-induced immunosuppressed rats. We found that DALI02 and DALI02 + Prebiotics, especially DALI02 + Prebiotics, exhibited significant restorative effects on the immunocompromised state in rats ( < .