0.43 J/100 ps Nd:YAG laser with adaptive compensation of thermally induced lens.

We demonstrate a diode-pumped master oscillator power amplifier Nd:YAG 1064 nm laser with sub-joule-level output energy of 0.43 J, high pulse repetition rate of 200 Hz, and short pulse duration of 100 ps. The 5 mJ master oscillator consisted of a 100 nJ/100 ps Nd:YVO microchip laser and end-pumped Nd:YAG regenerative amplifier.

[The influence of beta-adrenoblocking therapy on the markers of systemic inflammation in patients with acute coronary syndrome].

The study was designed to estimate activity of a series of anti-inflammatory markers (C-reactive protein (CRP), ceruloplasmin, haptoglobulin, interleukin (IL)-4, and IL-8) in the acute phase of acute coronary syndrome (ACS) and effect of beta-adrenoblocking therapy on their activity. The patients were divided into 2 groups: one was treated with beta-blocker metoprolol tartrate as a main component of ACS pharmacotherapy (n = 30), the other included the patients with absolute contraindications to bena-adrenoblockers (n = 15). Otherwise, patients of both groups received standard antianginal therapy including nitrates, anticoagulants, ACE inhibitors, and statins.

[Study of complexes of ethidium bromide with DNA by differential pulse voltammetry].

The interaction of ethidium bromide with calf thymus DNA was investigated by the method of differential pulse voltammetry. It was found that ethidium bromide binds with DNA in several ways. Corresponding values of the constants and the number of binding sites were determined.

[Case of chronic radiation sickness with subsequent leukemia in track driver subjected to long-external gamma-irradiation (cesium-137)].

The article deals with consequences seen in track driver after prolonged exposure to radiation caused by "lost" gamma-source (cesium-137) that long remained in receptacle of the vehicle's left door. Radiation dose averaged 8 Gy. The authors presented clinical manifestations, changes in peripheral blood and bone marrow, cytogenetic data by progression of radiation hemopoiesis hypoplasy to myelodysplastic syndrome and to acute leukaemia.

[Advances and difficulties of present-day treatment of acute myeloblastic leukemia].

The success in acute myeloblastic leukemia (AML) treatment for the last 10 years has been referred to growing intensity of chemotherapy. The efficacy of treatment has been assessed in 56 patients under 60 years of age. Double induction of remission according to the scheme TAD-9 (2-day administration of cytosar) and consolidation by large-dose cytosar (1 g/m2) with rubomycin have increased the frequency of 2-year recurrence-free running from 13 to 35%.

[Clinical-laboratory parallels in crush syndrome].

Biochemical evaluation of 60 patients with crush syndrome developing after the Armenian earthquake demonstrated informative value of some parameters: total blood protein, aspartate and alanine aminotransferase, myoglobin and middle-mass molecules. An aggravation of the disease accompanied acute renal failure and concomitant injuries. The above parameters proved valuable criteria in diagnosis of the clinical alterations.

[Colonoscopy in the diagnosis and treatment of small colonic polyps].

The results of treatment of 801 patients are analysed. It is shown that the probability of growth and the development of new adenomas or a recurrence of the disease is higher in patients with multiple small polyps and in their combination with larger structures. Therefore, all multiple structures in the colon, irrespective of their size, must be removed endoscopically without fail and the patients kept under dynamic control subsequently.

[A DNA study of rat liver oligonucleosomes enriched by transcriptionally active genes during induction due to the administration of an amino acid mixture].

A highly active fraction of rat liver oligonucleosome DNA has been isolated and studied by means of thermal denaturation after induction by amino acid mixture or hydrocortisone. A considerable redistribution of DNA content has been shown in sucrose gradient fractions during these forms of induction. The changes are revealed in melting temperature, differential melting profile of DNA, isolated from actively transcribed chromatine fractions.

[Physicochemical parameters of rat liver chromatin during nonhormonal induction].

The changes of RNA-polymerase activity of hepatocytes nuclei, chromatin circular dichroism (CD) spectra and differential melting curves of hepatocytes of rats which were injected hydrocortisone or amino acid mixture intraperitoneally have been studied. Actinomycin D reduces essentially RNA-polymerase activity and maximum of CD spectra. Under the influence of hydrocortisone or amino acid mixture the inhibiting action of antibiotic is taken off but the RNA-polymerase activity and maximum of CD spectra don't achieve the meanings found under the influence of inductors only.